Results 221 to 230 of about 2,900,820 (292)

ECSFinder: optimized prediction of evolutionarily conserved RNA secondary structures from genome sequences. [PDF]

Nucleic Acids Res
Gaonac'h-Lovejoy V, Mattick JS, Sauvageau M, Smith MA.   +3 more
europepmc   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Degenerate primers based on highly conserved regions of amino acid sequence in papillomaviruses can be used in a generalized polymerase chain reaction to detect productive human papillomavirus infections

, 1991
Peter J.F. Snijders, Chris J.L.M. Meijer, Jan M.M. Walboomers   +2 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Predicting the DNA binding specificity of transcription factor mutants using family-level biophysically interpretable machine learning. [PDF]

Nucleic Acids Res
Liu S, Gomez-Alcala P, Leemans C, Glassford WJ, Melo LAN, Lu XJ, Mann RS, Bussemaker HJ.   +7 more
europepmc   +1 more source

The Base Sequence Corresponding to DYZ1 is Detectable in the DNA from Many Animal Species.

, 1992
Yohsuke Higashi, Makoto Iwaya, Masahiko Saga, Shyoso OGAWA   +3 more
openalex   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Nanopore-Aware Embedded Detection for Mobile DNA Sequencing: A Viterbi-HMM Design Versus Deep Learning Approaches. [PDF]

Biosensors (Basel)
Hammad K, Wu Z, Ghafar-Zadeh E, Magierowski S.   +3 more
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Fitness landscapes and thermodynamic approaches to development of nucleic acids enzymes: from classical methods to AI integration. [PDF]

RSC Chem Biol
Takahashi S, Hamada M, Tateishi-Karimata H, Sugimoto N.   +3 more
europepmc   +1 more source