Results 71 to 80 of about 8,322,522 (296)
The Impact of Data Granularity of Indoor Temperature Measurements on the Calculation of Degree Days
Degree-days are to normalise energy consumption data and furthermore can generate forecasting predictions for energy demand being used to compare between different properties across different location and years. The base temperature is the main factor to
Mei Xue, Jimenez-Bescos Carlos
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
blu-base/tesla-pump-design-optimization: First release
Multi-objective Design Optimization of a Tesla-type Rotary Blood ...
blu-base
core +1 more source
Thermal-based germination models are widely used to predict germination rate and germination timing of plants. However, comparison of model parameters between large numbers of species is rare. In this study, seeds of 27 species including 12 C4 and 15 C3
Hongxiang Zhang, Yu Tian, Daowei Zhou
doaj +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Op covid.smartgraph.bi wordt de actuele data van RIVM en Stichting NICE hanteerbaar gemaakt in een onafhankelijk, interactief, dashboard. Men kan direct inzicht krijgen in de ontwikkelingen rondom COVID-19, omdat in het interactieve dashboard de data van
Quant Base
core
The research carried out as part of this EngD is aimed at understanding the high temperature materials used in modern gas turbine applications and providing QinetiQ with the information required to assess component performance in new propulsion systems ...
Everitt, S.
core +1 more source

