Results 171 to 180 of about 2,107,603 (337)

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

open access: yesAggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang   +12 more
wiley   +1 more source

Epithelial Folding Through Local Degradation of an Elastic Basement Membrane Plate

open access: yesAdvanced Physics Research
Epithelia are polarized layers of cells that line the outer and inner surfaces of organs. At the basal side, the epithelial cell layer is supported by a basement membrane, which is a thin polymeric layer of self‐assembled extracellular matrix (ECM) that ...
K. Yanín Guerra Santillán   +3 more
doaj   +1 more source

The Biosynthesis of Basement‐Membrane Collagen by Isolated Rat Glomeruli [PDF]

open access: bronze, 1975
Michael E. Grant   +2 more
openalex   +1 more source

Sensor‐Embedded Muscle for Closed‐Loop Controllable Actuation in Proprioceptive Biohybrid Robots

open access: yesAdvanced Intelligent Systems, EarlyView.
Skeletal muscle tissue‐based bioactuators move in response to externally applied electrical stimuli in open‐loop control, which lacks knowledge of the actuator's state. Herein, a soft and fiber‐shaped piezoresistive mechanosensor that integrates with the soft tissue and operates in the cell culture environment is used to create the first proprioceptive
Miriam Filippi   +8 more
wiley   +1 more source

Persistent Eosinophilic Inflammation Is Not a Feature of Type 2 CRS Patients Failing Anti‐IL‐5R Therapy and Requiring Class Switching to Anti‐IL‐4/13

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL‐4, ‐5, and ‐13 are prominent disease mediators. Disease control can be achieved with biologic therapies. However, despite some patients entering remission, others experience poor control. Aim We aimed to describe eCRS patients treated
Peta‐Lee Sacks   +8 more
wiley   +1 more source

MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu   +11 more
wiley   +1 more source

Differential Immune Cell Infiltration in Eosinophilic and Non‐Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty   +5 more
wiley   +1 more source

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