Results 261 to 270 of about 263,402 (283)

Altered Inflammatory Signature in a C9ORF72‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, EarlyView.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth. [PDF]

Front Bioeng Biotechnol
Zhou Y, Chen B, Ye S, Sun H, Wang S, Diao X, Wu W.   +6 more
europepmc   +1 more source

Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation. [PDF]

Mol Cancer
Kolarzyk AM, Kwon Y, Oh E, Lee KJ, Cho SY, Cano I, Lu R, Kwak TJ, Lee J, Wong G, Kim AH, Gandarilla O, Hidalgo M, Kim WK, Lee E.   +14 more
europepmc   +1 more source

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

Long-term alterations of collagen reconstruction and basement membrane regeneration after corneal full-thickness penetrating injury in rabbits. [PDF]

PLoS One
Chen J, Luo Y, Xie L, Meng N, Li S, Xiao S, Li X.   +6 more
europepmc   +1 more source

Pan‐cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors

International Journal of Cancer, EarlyView.
What's New? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Gongyu Tang, Xinyi Liu, Yuanxiang Li, Yunfei Ta, Minsu Cho, Hua Li, Xiaowei Wang   +6 more
wiley   +1 more source

Rapidly Progressive Glomerulonephritis Associated With Anti-glomerular Basement Membrane Disease: A Rare Diagnosis. [PDF]

Cureus
Maia C, Rocha J, Cardoso H, Antunes T, Almeida JS.   +4 more
europepmc   +1 more source

Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (TSCC)

International Journal of Cancer, EarlyView.
What's New? Human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (TSCC) is suspected of originating from tonsillar crypts, where HPV can persist in latent form. Detection is further complicated by the possible absence of premalignant stages, namely carcinoma in situ (CIS). Here, the authors investigated tumor origin in HPV‐associated
Tobias Näsman, Madeleine Birgersson, Linda Marklund, Anders Näsman   +3 more
wiley   +1 more source