Results 21 to 30 of about 256 (239)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Revista Chilena de Entomología, 2023 Las abejas son los principales polinizadores en los hábitats naturales, permitiendo tener ecosistemas resilientes. En este estudio se determinó la riqueza, abundancia y densidad de nidos, distribución espacial y tipos de anidación de abejas sin aguijón ...
Pedro Fernando Silva Illescas +5 more
doaj +1 more source
Bases científicas para una ciudad resiliente
, 2019 El 2 de abril de 2013, la región de La Plata, Berisso y Ensenada sufrió la peor inundación de su historia; la catástrofe se cobró la vida de decenas de personas. Ante la crisis, la Universidad Nacional de La Plata no dudó en poner en valor su compromiso con las necesidades de la comunidad. Como universidad pública, siempre ha considerado una obligación
Romanazzi, Pablo Gustavo +3 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Boletim do Observatório Ambiental Alberto Ribeiro LamegoDiante dos desafios globais decorrentes da degradação ambiental e das mudanças climáticas, torna-se essencial repensar a forma como os hospitais são projetados, construídos e operados, buscando soluções sustentáveis e resilientes que minimizem impactos ...
João Paulo Lucchetta Pompermaier +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
La Educación para la Salud en Educación Infantil: Elementos clave para su inclusión en las aulas
Sociedad e InfanciasEl presente artículo examina la Educación para la Salud (EpS) en la Educación Infantil, destacando el rol activo de los infantes como agentes que inciden en su propio bienestar y en el entorno.
Laura Fornons Casol, Anabel Ramos-Pla
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source