Results 21 to 30 of about 250 (233)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Uma análise de artigos sobre resiliência a partir de uma leitura Kleiniana

Psicologia em Estudo, 2011
Com o objetivo de compreender os mecanismos inconscientes que operam na resiliência, possibilitando que os indivíduos superem as adversidades e nestas encontrem formas criativas de superação, este artigo analisa a produção científica que utilizou ...
Selma Aparecida Geraldo Benzoni, Cassia Regina Rodrigues Varga   +1 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Hospitais resilientes e autossuficientes: uma análise da integração entre tecnologias emergentes e sustentabilidade

Boletim do Observatório Ambiental Alberto Ribeiro Lamego
Diante dos desafios globais decorrentes da degradação ambiental e das mudanças climáticas, torna-se essencial repensar a forma como os hospitais são projetados, construídos e operados, buscando soluções sustentáveis e resilientes que minimizem impactos ...
João Paulo Lucchetta Pompermaier, Elza Maria Alves Costeira, Patrícia Biasi Cavalcanti   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

La Educación para la Salud en Educación Infantil: Elementos clave para su inclusión en las aulas

Sociedad e Infancias
El presente artículo examina la Educación para la Salud (EpS) en la Educación Infantil, destacando el rol activo de los infantes como agentes que inciden en su propio bienestar y en el entorno.
Laura Fornons Casol, Anabel Ramos-Pla
doaj   +1 more source

Enfoques de evaluación creativa para las interacciones humanas y la tecnología de interfaces musicales. Una revisión sistemática de la literatura

Revista Electrónica Complutense de Investigación en Educación Musical, 2022
Este artículo revisa el estado del arte de las investigaciones que han evaluado hasta el momento las interacciones entre los humanos y las tecnologías musicales.
César Daniel Pascual-Vallejo, Sonia Casillas-Martín, Marcos Cabezas-González   +2 more
doaj   +1 more source

Análisis comparativo de habitabilidad entre una vivienda diseñada tradicionalmente y una vivienda con base en criterios sostenibles y resilientes enfocados en la optimización de recursos y uso de energías renovables

Ciencia Latina Revista Científica Multidisciplinar, 2022
La investigación se centra en el análisis de estudios realizados entre una vivienda diseñada tradicionalmente situada en el norte de la ciudad de Guayaquil, en la ciudadela orquídeas manzana 1053 v10, cuyas principales vías de acceso son la calle vehicular 11A NO que colinda en su norte con 1 Paseo 24A NO y hacia el sur con la calle 24A NO, con una ...
openaire   +1 more source