Results 31 to 40 of about 250 (233)

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Os profissionais de saúde no combate às alterações climáticas

RevSALUS, 2023
Já nos defrontamos, quase diariamente, com problemas associados às alterações climáticas, nomeadamente através dos seus impactes diretos e indiretos na nossa saúde.
Susana Paixão
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Ciudades inteligentes sostenibles: tecnología, inclusividad, equidad y medio ambiente

Clío
El documento intenta explorar el vínculo de las smart cities con políticas públicas mediadas por tecnologías disruptivas para la inclusividad, equidad, medio ambiente y sostenibilidad. Se utilizó una metodología con enfoque hermenéutico-valorativo de la
Perggi Aymeth Luyo Peralta, Olga Lidia Martínez Guerrera, Paulo César Novoa Vigo, Bógard Martín Terrones Cevallos   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Apoyo psicopedagógico y rendimiento académico en familias monoparentales rurales: revisión de la literatura

Revista Caribeña de Investigación Educativa
El rendimiento académico de estudiantes de familias monoparentales rurales enfrenta desafíos asociados a limitaciones socioeconómicas, escaso acompañamiento escolar y barreras estructurales.
Elmer Joel Soliz-Funes, Annia Almeyda-Vázquez   +1 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Uso de resíduo fresado de pavimento asfáltico para melhoria de solo laterítico argiloso em base de rodovias

Transportes
O aumento da produção de resíduo fresado de pavimento asfáltico tem promovido a necessidade de realizar pesquisas sobre seu reaproveitamento na construção de camadas de suporte em obras rodoviárias, visando ganhos ambientais e econômicos.
Gustavo Antezana Fajardo, Clara Souza de Oliveira, Rafael Ribeiro Plácido, Tiago de Jesus Souza, Fernando Luiz Lavoie   +4 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source