Results 31 to 40 of about 252 (233)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Ciudades inteligentes sostenibles: tecnología, inclusividad, equidad y medio ambiente
El documento intenta explorar el vínculo de las smart cities con políticas públicas mediadas por tecnologías disruptivas para la inclusividad, equidad, medio ambiente y sostenibilidad. Se utilizó una metodología con enfoque hermenéutico-valorativo de la
Perggi Aymeth Luyo Peralta +3 more
doaj +1 more source
Este artículo revisa el estado del arte de las investigaciones que han evaluado hasta el momento las interacciones entre los humanos y las tecnologías musicales.
César Daniel Pascual-Vallejo +2 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
El rendimiento académico de estudiantes de familias monoparentales rurales enfrenta desafíos asociados a limitaciones socioeconómicas, escaso acompañamiento escolar y barreras estructurales.
Elmer Joel Soliz-Funes +1 more
doaj +1 more source
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
O aumento da produção de resíduo fresado de pavimento asfáltico tem promovido a necessidade de realizar pesquisas sobre seu reaproveitamento na construção de camadas de suporte em obras rodoviárias, visando ganhos ambientais e econômicos.
Gustavo Antezana Fajardo +4 more
doaj +1 more source
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Perspectiva de género en el abordaje de cambio climático y salud
La intensidad y devastación de los eventos climáticos del Siglo XXI incrementan la vulnerabilidad de personas con problemáticas sociohistóricas preestablecidas. Los impactos de cambio climático en salud no son lineales, se producen de forma diferenciada
Mónica Izurieta-Guevara
doaj +1 more source

