Results 31 to 40 of about 214 (204)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Os profissionais de saúde no combate às alterações climáticas
RevSALUS, 2023 Já nos defrontamos, quase diariamente, com problemas associados às alterações climáticas, nomeadamente através dos seus impactes diretos e indiretos na nossa saúde.
Susana Paixão
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Ciencia Latina Revista Científica Multidisciplinar, 2022 La investigación se centra en el análisis de estudios realizados entre una vivienda diseñada tradicionalmente situada en el norte de la ciudad de Guayaquil, en la ciudadela orquídeas manzana 1053 v10, cuyas principales vías de acceso son la calle vehicular 11A NO que colinda en su norte con 1 Paseo 24A NO y hacia el sur con la calle 24A NO, con una ...
openaire +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Boletim do Observatório Ambiental Alberto Ribeiro LamegoDiante dos desafios globais decorrentes da degradação ambiental e das mudanças climáticas, torna-se essencial repensar a forma como os hospitais são projetados, construídos e operados, buscando soluções sustentáveis e resilientes que minimizem impactos ...
João Paulo Lucchetta Pompermaier +2 more
doaj +1 more source
Cuadernos de Investigación Urbanística, 2022 Resumen La gestión del agua juega un papel fundamental para lograr entornos urbanos más resilientes e integrados con su medio a través de la optimización de sus lógicas metabólicas.
Joan Maria Martí Elias +1 more
doaj +1 more source
Mantova Resiliente : Mantova Resiliente: Linee guida per un adattamento climatico local-based [PDF]
, 2018 L’urbanizzazione e la sua relativa sostenibilità nel lungo periodo sono tra le sfide cruciali del nostro tempo (Bina et al., 2016). La città sotto la minaccia del cambiamento climatico e dei suoi impatti diventa, motore economico, sociale ed ambientale verso lo sviluppo sostenibile e la resilienza, pertanto, le trasformazioni urbane ne diventano le ...
Lucertini, Giulia +4 more
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