Results 71 to 80 of about 1,150,444 (321)

Racial Differences on Association of Depressive Symptoms With Combined Basic and Instrumental Activities of Daily Living [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013
Depressive symptoms are predictive of multiple degenerative diseases in older age adults. However, the association of depressive symptoms with onset and progression of disability have not been studied.In a cohort of community-dwelling, older black and white adults, 5,446 initially nondisabled subjects were followed annually for disability between 2000 ...
Kumar B, Rajan, Lisa L, Barnes, Robert S, Wilson, Denis A, Evans, Carlos F, Mendes de Leon   +4 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Association of body mass index with disability in activities of daily living in older adults: a systematic review of the literature based on longitudinal data

BMC Public Health
Background The influence of Body Mass Index (BMI) on the functional capacity for daily activities in older adults is a significant concern. Our study is designed to delineate the longitudinal relationship between BMI and the ability of daily living ...
Wang Lingying, Zhu Hong, Chen Hongxiu, Hu Ziyi, Feng Mei, Tang Menglin, Hu Xiuying   +6 more
doaj   +1 more source

The effects of donepezil in Alzheimer's disease - Results from a multinational trial [PDF]

, 1999
Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD).
Burns, A., Friedhoff, L. T., Gauthier, S., Hecker, J., Möller, Hans-Jürgen, Petit, H., Rogers, S. L., Rossor, M.   +7 more
core   +1 more source

Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living [PDF]

Journal of Neurology, 2019
Impairments in activities of daily living (ADL) are a criterion for Alzheimer's disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self ...
Slachevsky Chonchol, Andrea, Forno, Gonzalo, Barraza, Paulo, Mioshi, Eneida, Delgado, Carolina, Lillo, Patricia, Henríquez, Fernando, Bravo, Eduardo, Farías, Mauricio, Muñoz Neira, Carlos, Ibáñez, Agustín, Parra, Mario A., Hornberger, Michael   +12 more
openaire   +4 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Disabilty in Older Adults with Depression [PDF]

, 2005
Depression is a leading cause of disability among older adults which can change the scope of daily life for older adults and threaten their ability to live independently in the community.
Chisholm, Denise
core  

Factors influencing stroke survivors' reintegration into a rural community: Perspectives from a municipality in Limpopo Province, South Africa

South African Journal of Occupational Therapy
Background:  Stroke incidence remains high in South Africa.  Access to rehabilitation services is critical for stroke survivors to successfully reintegrate back into the community.  This study aimed to explore the factors that influence stroke survivors'
Lizzy Mashapa, Phakeme Charity Zinhle Mkhize, Deshini Naidoo   +2 more
doaj   +1 more source

A Survey of Basic Daily Living Assistance in Dependency Units during the Morning First Period at Nursing Homes with a Healthcare Dysfunction

Nursing Reports, 2022
(1) Background: It is important to evaluate the attention in the basic activities of daily life in the early hours of the day to evaluate the quality of care and to be able to increase the attention of human resources in case of observing an increase in ...
José Antonio Camacho-Conde, David Juan Muñoz-Arbona   +1 more
doaj   +1 more source