Results 31 to 40 of about 737,890 (266)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Basics of the density functional theory

AIMS Materials Science, 2017
The density functional theory (DFT) established itself as a well reputed way to compute the electronic structure in most branches of chemistry and materials science. In the formulation given by Kohn, Hohenberg and Sham in the 1960's, the many-electron wave function is replaced by the electron density, so that the energy is just a functional of the ...
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Universal basic mass density inside dark matter halos

Physica Scripta
Abstract In this work we propose a universal basic mass density and a universal basic metric inside dark matter halos in the framework of Einstein equations providing an analytical ground for learning about dark matter. In a previous work the authors have proposed a simplified model for galaxies: a Schwarzschild black hole (that contains
Nidal Haddad, Fateen Haddad
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Neuro-fuzzy Hybrid System for Monitoring Wood Moisture Content During Drying

Floresta e Ambiente, 2019
The heterogeneous behavior of wood during drying is a process difficult to control. The objective of this study was to evaluate the accuracy of the neuro-fuzzy hybrid system for monitoring wood moisture during drying.
Antônio José Vinha Zanuncio, Amélia Guimarães Carvalho, Carlos Alberto Araújo Júnior, Maíra Reis de Assis, Liniker Fernandes da Silva   +4 more
doaj   +1 more source

Unconditional basic sequences in spaces of large density

Advances in Mathematics, 2011
We study the problem of the existence of unconditional basic sequences in Banach spaces of high density. We show, in particular, the relative consistency with GCH of the statement that every Banach space of density $\aleph_ $ contains an unconditional basic sequence.
Dodos, P., Lopez-Abad, J., Todorcevic, S.   +2 more
openaire   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Tensiones de crecimiento y propiedades físicas de la madera de Eucalyptus dunnii implantado en Argentina

Maderas: Ciencia y Tecnología, 2014
El objetivo del trabajo fue evaluar tensiones de crecimiento en Eucalyptus dunnii y determinar el efecto de las propiedades físicas de la madera sobre esta variable. Se muestrearon 45 árboles de un ensayo de 19 años situado en la provincia de Corrientes,
Mariano Hernández, Constantino Zaderenko, Silvia Monteoliva   +2 more
doaj