Results 71 to 80 of about 5,804,591 (298)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Basic Products Corporation Wholesale Price List

, 1918
After U.S. entry into the war, Hoosier businessmen travelled to Washington to see about procuring war contracts for Indiana industries. The state’s industries furnished war materials on a large scale, their total value approximating $300,000,000.
Basic Products Corporation
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USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Basic Biologocal Chemistry

, 1968
x.;ill.;527 hal.; 25 ...
Basic Biologocal Chemistry
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Morphodynamics of supercritical high-density turbidity currents [PDF]

, 2012
Seafloor and outcrop observations combined with numerical and physical experiments show that turbidity currents are likely 1) to be in a supercritical flow state and 2) to carry high sediment concentrations (being of high-density). The thesis starts with
Sedimentology, Cartigny, M., Coastal dynamics, Fluvial systems and Global change, Erosion and sedimentation by high-energy density turbity flows on steep slopes   +3 more
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Non-Destructive Evaluation of Wood Properties in Ficus variegata Blume: Implications for Breeding

Forest Science and Technology
Non-destructive evaluation (NDE) techniques are essential for assessing wood properties in standing trees to support genetic improvement programs. Ficus variegata Blume is a fast-growing native species in Indonesia with potential for plantation timber ...
Liliek Haryjanto, Sapto Indrioko, Arif Nirsatmanto, Fanny Hidayati, Rafif Pujasmara, Purnamila Sulistyawati, Noor Khomsah Kartikawati, Anto Rimbawanto, Sri Sunarti, Asri Insiana Putri, Toni Herawan, Fajar Lestari, Yayan Hadiyan   +12 more
doaj   +1 more source

CORRELATION OF ANATOMY WITH PHYSICAL PROPERTIES OF WOOD SPECIES FROM AN AGROFORESTRY SYSTEM [PDF]

Revista Árvore
When the premise is the best final use of wood, evaluation of anatomical variables is recommended, bearing in mind that they are correlated with the properties of this material.
Elder Eloy, Tauana de Souza Mangini, Claiton Nardini, Braulio Otomar Caron, Rômulo Trevisan, Alec Duwe dos Santos   +5 more
doaj   +1 more source

Spectrometric prediction of wood basic density by comparison of different grain angles and variable selection methods. [PDF]

Plant Methods, 2021
Li Y, Liu W, Cao R, Tan Z, Liu J, Jiang J.   +5 more
europepmc   +1 more source