Results 81 to 90 of about 5,804,591 (298)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Compression wood in Pinus radiata II: Density and chemical composition

Maderas: Ciencia y Tecnología, 2014
Ten 22 year old radiata pine trees growing in two stands in Chile, one in clay and the other in humid sand soils showing some lean, were assessed for chemical composition and wood density of compres-sion wood. Signifi cant differences in type of wood in
J. E. Diaz-vaz, R.A. Ananías, S. Rodríguez, M. Torres, A. Fernández, H. Poblete   +5 more
doaj  

Basic wood density tree species of Cerradão physiognomy in the state of Tocantins

Pesquisa Florestal Brasileira, 2015
The aim of this study was to analyze the basic density of tree species of Cerradão phytophysiognomy in Cerrado domain in the state of Tocantins, and establish the relationship between the wood basic density of stems and branches. Samples of 80 trees were
Carlos José da Silva, Ailton Teixeira do Vale, Eder Pereira Miguel   +2 more
doaj   +1 more source

Density Analysis of Basic Graphs and Their Corona Products

Asian Research Journal of Mathematics
This research paper explores the concept of density of graph, with a main focus on different graphs and their corona products. We have started with defining a few graphs like; path, cycle, ladder, kite, triangular snake, H, and circular ladder graph along with terms like order, size, and corona product of graph.
Kartikraj Dhamsaniya, Mehul Chaurasia
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Efecto del raleo en el crecimiento y algunas propiedades de la madera de Eucalyptus nitens en una plantación de 15 años Effect of thinning on growth and some properties of wood of Eucalyptus nitens in a plantation of 15 years old

Maderas: Ciencia y Tecnología, 2012
El raleo tiene implicancias económicas y técnicas tanto para producción forestal como para la actividad industrial. En el presente estudio se realizó la evaluación de un ensayo de intensidad de raleo en E.
Sandro Díaz Bravo, Miguel Espinosa, Luis Valenzuela, Jorge Cancino, Jean P Lasserre   +4 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Original pycnometers for volatile liquid density over wide ranges of temperature and pressure: practical example

, 2014
A novel kind of pycnometer was designed for liquid density measurements suitable to be used over wide ranges of temperature and pressure. Two similar pycnometers have been manufactured and tested with n-nonane 99.7mol% in the temperature range from 233K ...
Santiano M, LOREFICE, SALVATORE, Romeo R, Santiano, Marco, Capelli A., Capelli, Andrea, Romeo, Raffaella   +6 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source