Results 251 to 260 of about 233,973 (306)

The basic fibroblast growth factor‐saporin mitotoxin acts through the basic fibroblast growth factor receptor

Journal of Cellular Physiology, 1991
AbstractWe have confirmed the hypothesis that a mitotoxin resulting from the conjugation of basic fibroblast growth factor and saporin exerts its cytotoxic effect through specific interaction with the basic fibroblast growth factor (FGF) receptor. Accordingly, the mitotoxin stimulates tyrosine phosphorylation of the 90 kD substrate that characterizes ...
D A, Lappi, P A, Maher, D, Martineau, A, Baird   +3 more
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Vitreoretinal toxicity of basic fibroblast growth factor

International Ophthalmology, 1993
Basic fibroblast growth factor (b-FGF) is one of the multifunctional growth factors with important therapeutic potential in the field of ophthalmology. It is also implicated in pathogenesis of vitreoretinal proliferative diseases. In the present study, we evaluated its vitreoretinal toxicity by means of clinical observation, electroretinography (ERG ...
H, Borhani, G A, Peyman, M H, Rahimy, R W, Beuerman   +3 more
openaire   +2 more sources

Basic fibroblast growth factor in Alzheimer's disease

Biochemical and Biophysical Research Communications, 1990
We have examined the presence of basic fibroblast growth factor (FGF) in normal and in Alzheimer brains, studied the distribution of the mitogen by immunohistochemical techniques, measured the quantities of growth factor in selected areas of the brain (Brodmann areas 10/11 and 20/21), characterized the molecular forms by Western blotting and determined
E G, Stopa, A M, Gonzalez, R, Chorsky, R J, Corona, J, Alvarez, E D, Bird, A, Baird   +6 more
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Basic fibroblast growth factor and ovarian cancer

The Journal of Steroid Biochemistry and Molecular Biology, 1995
The factor(s) which regulate the rapid growth of ovarian epithelial carcinoma, as well as other types of malignant tumors, are still largely unknown. Recently, experimental evidence indicated that neoplastic cells are able to synthesize peptide growth factor and their receptors.
A M, Di Blasio, C, Carniti, P, Viganò, M, Vignali   +3 more
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Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium

Brain Research, 2001
Basic fibroblast growth factor (FGF2) stimulates proliferation of the globose basal cells, the neuronal precursor in the olfactory epithelium. The present study investigates the expression of basic fibroblast growth factor and fibroblast growth factor receptors in the adult olfactory epithelium.
Hsu, P, Yu, F, Feron, F, Pickles, JO, Sneesby, K, Mackay-Sim, A   +5 more
openaire   +4 more sources

Expression of acidic fibroblast growth factor and basic fibroblast growth factor in nasal polyps

Acta Oto-Laryngologica, 2006
Up-regulated expression of acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) in nasal polyps may be related to epithelial proliferation and neoangiogenesis associated with nasal polyp growth.aFGF and bFGF are polypeptides that effect mitogenesis, neoangiogenesis and tissue repair.
Hyung Jin, Kim, Hak Hyun, Jung, Sang Hak, Lee   +2 more
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Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor

Biochemistry, 1988
Incubation of bovine brain derived acidic fibroblast growth factor (aFGF) with bovine or human thrombin, 0.5 NIH unit/mL, for 24 h at 37 degrees C results in cleavage of the mitogen, generating a 14-kilodalton fragment which has significantly reduced affinity for immobilized heparin as compared to aFGF, and is at least 50-fold less potent at ...
openaire   +2 more sources

Complexation of basic fibroblast growth factor with gelatin

Journal of Biomaterials Science, Polymer Edition, 1998
Polyion complexation between basic fibroblast growth factor (bFGF) and gelatin was studied by the turbidity change of mixed solution, heparin high performance liquid affinity chromatography (HPLAC), and isoelectric electrophoresis. When an aqueous solution of acidic gelatin with an isoelectric point (IEP) of 5.0 was mixed with that of bFGF, the ...
, Muniruzzaman, Y, Tabata, Y, Ikada
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Recombinant basic fibroblast growth factor accelerates wound healing

Journal of Surgical Research, 1988
Basic fibroblast growth factor (bFGF) stimulates extracellular matrix metabolism, growth, and movement of mesodermally derived cells. We have previously shown that collagen content in polyvinyl alcohol sponges increased after bFGF treatment. We hypothesized that bFGF-treated incisional wounds would heal more rapidly. After intraperitoneal pentobarbital
G S, McGee, J M, Davidson, A, Buckley, A, Sommer, S C, Woodward, A M, Aquino, R, Barbour, A A, Demetriou   +7 more
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Basic fibroblast growth factor in rat salivary glands

Cell & Tissue Research, 1993
We studied the occurrence and localization of basic fibroblast growth factor (bFGF) in rat salivary glands using a specific monoclonal antibody. It was shown that the extract of rat salivary glands has a pronounced stimulatory activity on the growth of bovine capillary endothelial cells, which is blocked by the addition of an antibody against bFGF. The
O, Amano, Y, Yoshitake, K, Nishikawa, S, Iseki   +3 more
openaire   +2 more sources