Results 71 to 80 of about 107,836 (184)

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway*

Journal of Biological Chemistry, 1997
In an effort to better understand the mechanism of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin, we employed an iterative search of human expressed sequence tags to identify novel basic-helix-loop-helix-PAS (bHLH-PAS) proteins that interact with ...
J. Hogenesch, W. Chan, V. Jackiw, Brownlee Rc, Yinhong Gu, Marilyn G. Pray-Grant, G. Perdew, C. Bradfield   +7 more
semanticscholar   +1 more source

Phosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.

PLoS ONE, 2011
BackgroundThe Twist1-family basic helix-loop-helix (bHLH) transcription factors including Twist1, Hand1 and Hand2, play an essential role in heart development and are implicated in pathological heart remodeling.
Shuangshuang Lu, Junwei Nie, Qing Luan, Qiuting Feng, Qi Xiao, Zai Chang, Congjia Shan, Daniel Hess, Brian A Hemmings, Zhongzhou Yang   +9 more
doaj   +1 more source

The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis.

Genome Research, 2001
The basic Helix-Loop-Helix (bHLH) proteins are transcription factors that play important roles during the development of various metazoans including fly, nematode, and vertebrates. They are also involved in human diseases, particularly in cancerogenesis.
Valérie Ledent, Michel Vervoort
semanticscholar   +1 more source

The bHLH Transcription Factor PhbHLH121 Regulates Response to Iron Deficiency in Petunia hybrida

Plants
Iron (Fe) is an essential micronutrient for plants. Due to the low Fe bioavailability in cultivated soils, Fe deficiency is a widespread agricultural problem.
Liru Pan, Chengcheng Huang, Ruiling Li, Yanbang Li   +3 more
doaj   +1 more source

Tipping the MYC–MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC‐activated genes

EMBO Molecular Medicine, 2014
MYC family oncoproteins (MYC, N‐MYC and L‐MYC) function as basic helix‐loop‐helix‐leucine zipper (bHLH‐Zip) transcription factors that are activated (i.e., overexpressed) in well over half of all human malignancies (Boxer & Dang, 2001; Beroukhim et al ...
Franz X Schaub, John L Cleveland
doaj   +1 more source

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Nature Communications, 2018
Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear.
Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja, Daniel G. Tenen   +17 more
doaj   +1 more source

Evolution and diversification of the ACT-like domain associated with plant basic helix-loop-helix transcription factors. [PDF]

Proc Natl Acad Sci U S A, 2023
Lee YS, Shiu SH, Grotewold E.
europepmc   +1 more source

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Guang-lei Wang, B. Jiang, E. Rue, G. Semenza   +3 more
semanticscholar   +1 more source

The Basic/Helix-Loop-Helix Transcription Factor Family Gene RcbHLH112 Is a Susceptibility Gene in Gray Mould Resistance of Rose (Rosa Chinensis). [PDF]

Int J Mol Sci, 2023
Ding C, Gao J, Zhang S, Jiang N, Su D, Huang X, Zhang Z.   +6 more
europepmc   +1 more source

PsPRE1 is a basic helix-loop-helix transcription factor that confers enhanced root growth and tolerance to salt stress in poplar. [PDF]

For Res (Fayettev), 2023
Du J, Ge X, Wei H, Zhang M, Bai Y, Zhang L, Hu J.   +6 more
europepmc   +1 more source