Results 111 to 120 of about 148,826 (294)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Tcf15 Primes Pluripotent Cells for Differentiation

Cell Reports, 2013
The events that prime pluripotent cells for differentiation are not well understood. Inhibitor of DNA binding/differentiation (Id) proteins, which are inhibitors of basic helix-loop-helix (bHLH) transcription factor activity, contribute to pluripotency ...
Owen R. Davies, Chia-Yi Lin, Aliaksandra Radzisheuskaya, Xinzhi Zhou, Jessica Taube, Guillaume Blin, Anna Waterhouse, Andrew J.H. Smith, Sally Lowell   +8 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Seed Coat Pattern QTL and Development in Cowpea (Vigna unguiculata [L.] Walp.)

Frontiers in Plant Science, 2019
The appearance of the seed is an important aspect of consumer preference for cowpea (Vigna unguiculata [L.] Walp.). Seed coat pattern in cowpea has been a subject of study for over a century.
Ira A. Herniter, Ryan Lo, María Muñoz-Amatriaín, Sassoum Lo, Yi-Ning Guo, Bao-Lam Huynh, Mitchell Lucas, Zhenyu Jia, Philip A. Roberts, Stefano Lonardi, Timothy J. Close   +10 more
doaj   +1 more source

Role of the PAS2 domain of the NifL regulatory protein in redox signal transduction [PDF]

, 2010
EThOS - Electronic Theses Online ServiceGBUnited ...
Slavny, Peter
core  

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA. [PDF]

, 2019
Many intracellular bacteria, including Chlamydia, establish a parasitic membrane-bound organelle inside the host cell that is essential for the bacteria\u27s survival.
Bryer, Alexander J, Cingolani, Gino, Greco, Deanna L, Lobley, Anna, Lokareddy, Ravi K, McCauley, Michael, Paumet, Fabienne, Perilla, Juan R, Ronzone, Erik, Wesolowski, Jordan   +9 more
core   +1 more source

Chirality and Protein Folding

, 2004
There are several simple criteria of folding to a native state in model proteins. One of them involves crossing of a threshold value of the RMSD distance away from the native state. Another checks whether all native contacts are established, i.e. whether
Bernstein F C, Cieplak M, Cieplak M, Joanna I Kwiecińska, Kolinski A, Li M S, Marek Cieplak, Veitshans T   +7 more
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

Cell Reports, 2013
Cell fate is governed by combinatorial actions of transcriptional regulators assembling into multiprotein complexes. However, the molecular details of how these complexes form are poorly understood.
Kamel El Omari, Sarah J. Hoosdally, Kapil Tuladhar, Dimple Karia, Elisa Hall-Ponselé, Olga Platonova, Paresh Vyas, Roger Patient, Catherine Porcher, Erika J. Mancini   +9 more
doaj   +1 more source