Results 41 to 50 of about 29,990 (187)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

Generalizations of Ramanujan's reciprocity formula and the Askey-Wilson integral [PDF]

open access: yes, 2013
By using two known transformation formulas for basic hypergeometric series, we establish a direct extension of Bailey's $_6\psi_6$-series identity. Subsequently, it and Milne's identity are employed to drive multi-variable generalizations of Ramanujan's ...
Wang, Xiaoxia   +2 more
core  

Monocytes with trained immunity–like signatures are associated with acute anterior uveitis in ankylosing spondylitis

open access: yesInterdisciplinary Medicine, EarlyView.
In ankylosing spondylitis‐acute anterior uveitis (AS‐AAU), trained immunity monocytes (Mono‐TI) differentiate into macrophages in the eye, retaining trained immunity features. Mono‐TI cells secrete pro‐inflammatory cytokines and chemokines, including IL‐1β, TNF‐α, and CCL3.
Yimeng Sun   +13 more
wiley   +1 more source

A highly accurate numerical method for solving boundary value problem of generalized Bagley‐Torvik equation

open access: yesMathematical Methods in the Applied Sciences, EarlyView.
A highly accurate numerical method is given for the solution of boundary value problem of generalized Bagley‐Torvik (BgT) equation with Caputo derivative of order 0<β<2$$ 0<\beta <2 $$ by using the collocation‐shooting method (C‐SM). The collocation solution is constructed in the space Sm+1(1)$$ {S}_{m+1}^{(1)} $$ as piecewise polynomials of degree at ...
Suzan Cival Buranay   +2 more
wiley   +1 more source

Theta Functions, Elliptic Hypergeometric Series, and Kawanaka's Macdonald Polynomial Conjecture

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2009
We give a new theta-function identity, a special case of which is utilised to prove Kawanaka's Macdonald polynomial conjecture. The theta-function identity further yields a transformation formula for multivariable elliptic hypergeometric series which ...
Robin Langer   +2 more
doaj   +1 more source

A simple proof of Bailey's very-well-poised 6-psi-6 summation

open access: yes, 2000
We give elementary derivations of some classical summation formulae for bilateral (basic) hypergeometric series. In particular, we apply Gauss' 2-F-1 summation and elementary series manipulations to give a simple proof of Dougall's 2-H-2 summation ...
Schlosser, M.
core   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

open access: yesSmall Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto   +12 more
wiley   +1 more source

Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li   +9 more
wiley   +1 more source

A short proof of an identity of Sylvester

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1999
We present two short proofs of an identity found by Sylvester and rediscovered by Louck. The first proof is an elementary version of Knuth's proof and is analogous to Macdonald's proof of a related identity of Milne.
Gaurav Bhatngar
doaj   +1 more source

Modeling of regional magnetic field applying spherical functions: theoretical aspect

open access: yesГеофизический журнал, 2019
Observation of geomagnetic field, measurement of its components values and establishment on their base models of geomagnetic field as well as geomagnetic mapping are the main trend of geomagnetic studies.
Yu. P. Sumaruk   +2 more
doaj   +1 more source

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