Results 131 to 140 of about 88,645 (280)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Influence of cataract surgery in biopsychosocial adaptation in the elderly

Medisur, 2010
Background: The twenty-first century is characterized by a progressive aging in the population, with the subsequent demand of medical care it implies due to the polimorbility rates typical of this stage of life. Objective: to prove the positive influence
Leonor Rosario Diaz Alfonso, Elvira Machado Héctor, Bárbara Suárez Rodríguez, Mariela Julia Curbelo Gómez   +3 more
doaj   +2 more sources

Studies on high-temperature life property of the ceramic bearing (Part 1) ー The basic load rating of the lubricating in high-temperature atmospheric air ー

, 2013
Practical use level has the ceramic bearing which is superior in a high temperature characteristic, and it is important to demand the rating lift of the ceramic bearing under various conditions.
カワグチ, サトシ, 川口, 悟史, 市川, 茂樹, 瀬山, 知亮, ICHIKAWA, Shigeki, 301, 302, 303, KAWAGUCHI, Satoshi, SEYAMA, Hajime, セヤマ, ハジメ, 304, イチカワ, シゲキ, 305, 306   +14 more
core  

Escitalopram reduces severity of depression and improves quality of life in patients with chronic obstructive pulmonary disease in an open label parallel group study

, 2016
Background: Chronic obstructive pulmonary disease (COPD) is characterised by progressive and persistent airflow limitation with frequent exacerbations and hospitalizations contributing to overall morbidity and mortality.
P., Vignan Kumar G., Channareddy, Lakshmi Rajesh, Ravula, Eshwar Reddy   +2 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effective pre-school, primary and secondary education project (EPPSE 3-14) : students' reports of their experiences in year 9 [PDF]

, 2011
The Effective Pre-school, Primary and Secondary Education Project (EPPSE) has inves tigated the academic and social behavioural (+ in the later stages the affective) development of approximately 3,000 children from the age of 3+ years since 1997.
Smees, R., Draghici, D., Smees, R, Siraj-Blatchford, Iram, Toth, Katalin, Taggart, Brenda, Taggart, B., Sylva, K., Melhuish, E, Sammons, Pam, Sammons, P., Siraj-Blatchford, I, Sammons, Pamela, Draghici, Diana, Sammons, P, Draghici, D, Smees, Rebecca, Sylva, K, Sylva, Kathy, Toth, K, Toth, K., Siraj-Blatchford, I., Melhuish, Edward, Melhuish, Edward C., Taggart, B   +24 more
core  

Efficacy, acceptability, and safety of adjunctive aripiprazole in treatment-resistant depression: a meta-analysis of randomized controlled trials

Neuropsychiatric Disease and Treatment, 2018
Shuxin Luan,1,2 Hongquan Wan,2 Lei Zhang,3 Hua Zhao1,4 1Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun, China; 2Department of Mental Health, The First Hospital of Jilin University, Changchun, China; 3Department ...
Luan SX, Wan HQ, Zhang L, Zhao H
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source