Results 151 to 160 of about 88,645 (280)

Cockpit Text Communications: Evaluating the Efficiency and Accuracy

, 2013
Non-voice data exchanges will become a primary method of communication between pilots and Air Traffic Controllers as the Federal Aviation Administration’s plan for the Next Generation Air Traffic Control System (NextGen) evolves.
Ziemba, Adam J., Fanjoy, Richard O., Carney, Thomas Q., Petrin, Donald A.   +3 more
core  

Perceptions of Female Abdominal Muscle Definition: A Crowdsourced Analysis of Contour Preferences. [PDF]

Aesthet Surg J Open Forum
Bhatia SS, Steppe C, Niksic A, Wen YE, Layt WOW, Aly A.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Factors associated with the mental health of parents during and after their child's hospitalisation: an international longitudinal prospective cohort study. [PDF]

BMJ Ment Health
Mehra R, Hoffmann TJ, Graham-Squire D, Lisanti AJ, Gay C, Hodgson C, Rienks J, Pavlik M, Manju S, Turaga N, Clay M, Franck LS.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Experimental Study of the Efect of Lubricants on Rolling Contact Life

, 2014
The aim of this bachelor’s thesis is to summarize the art of state in the area of the contact fatigue, lubricants and detection of the rolling contact fatigue exploiting the acoustic emission method. In the experimental part of this bachelor’s thesis are
Šembera, Václav
core  

Influence of Social Support and Quality of Life on Mortality Among Patients Undergoing Hemodialysis. [PDF]

J Nurs Res
Zhang L, Zhang Y, Zhang S, Tang X, Shi S, Quan H, Yang X.   +6 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The relationship between shyness and short video addiction among college students: chain mediating role of social support and basic psychological needs. [PDF]

Front Psychol
Bu X, Li X, Li B, Zhang X.
europepmc   +1 more source