Results 171 to 180 of about 8,297,014 (304)

The Clinical View of Sepsis-Associated AKI: How Basic Science Can Help Solve This Problem. [PDF]

Semin Nephrol
Odum JD, Hasson DC, Stanski NL, Gómez H, Soranno DE.   +4 more
europepmc   +1 more source

Membranous nephropathy: integrating basic science into improved clinical management.

Kidney International, 2017
D. Cattran, P. Brenchley
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Retention of physiology knowledge among medical students in basic science: a cross-sectional study. [PDF]

BMC Med Educ
Hadad MK, Dehghani MR, Okhovati M, Shafian S.   +3 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Restoration of High-Frequency Middle Ear Function in Partial Ossicular Discontinuity: A Basic Science and Clinical Correlation. [PDF]

Otol Neurotol
Fallon K, Inuzuka Y, Cheng JT, Rosowski JJ, Remenschneider AK.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

EUROBIOFILMS 2024 - From environment and basic science to serious clinical infections - bridging for solutions. [PDF]

Biofilm
Moser C, Bjarnsholt T, Thomsen TR.
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Mind the Translational Gap: Bidirectional Disease Associations Emphasize Need for Basic Science and Prospective Trials. [PDF]

JACC CardioOncol
Bell C.
europepmc   +1 more source