Results 51 to 60 of about 8,297,014 (304)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Calibration of Transit Operations Planning (TOP) Model and Evaluation of Bus Transit Route Performance in Riyadh

Sultan Qaboos University Journal for Science, 1997
Public transit systems provide mobility for a large percentage of urban residents very cost-effectively and with minimum negative impact on the environment.
P.A. Koushki, G.A. Ali, Y.A. Al-Nuaim
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Mycoflora and Mycotoxigenic Moulds of Pistachio Nuts for Human Consumption in the Sultanate of Oman

Sultan Qaboos University Journal for Science, 1998
Mycoflora of 75 cans of different batches and brands of pistachio nuts purchased in the Sultanate of Oman was studied. A number of fungi were isolated, with percentages of contaminated nuts [average between brands ] as follows: Aspergillus niger 14.8 ...
A. E. Elshafie, N. S. AL-Shally
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Constructing Node-Disjoint Routes in K-Ary N-Cubes

Sultan Qaboos University Journal for Science, 1997
In this paper, a method for constructing node-disjoint (parallel) paths in k-ary n-cube interconnection networks is described. We start by showing in general how to construct parallel paths in any Cartesian product of two graphs based on known paths in ...
Khaled Day, Abdel Elah Al-Ayyoub
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Distributed Simulation of Open Cyclic Queuing Networks

Sultan Qaboos University Journal for Science, 1997
In this paper we present the results of an experimental performance study of distributed simulation of open cyclic queuing networks using a minor variation of the deadlock detection and recovery based algorithm of Chandy and Misra. One major part of this
Saad Harous
doaj   +1 more source

Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach

Journal of Experimental Orthopaedics, 2017
Chronic tendinopathies represent a major problem in the clinical practice of sports orthopaedic surgeons, sports doctors and other health professionals involved in the treatment of athletes and patients that perform repetitive actions.
F. Abat, H. Alfredson, H. Alfredson, M. Cucchiarini, H. Madry, A. Marmotti, C. Mouton, J. Oliveira, H. Pereira, H. Pereira, G. Peretti, D. Romero-Rodriguez, D. Romero-Rodriguez, C. Spang, Joanna M Stephen, C. V. Bergen, L. Girolamo   +16 more
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source