Results 71 to 80 of about 6,234,437 (297)

Immersion in Physiology Bolsters Bedside Mechanistic Thinking [PDF]

, 2019
Purpose and Background: Compression of education and training with other responsibilities into more limited work hours Shift towards algorithm-based teaching/practice Less time spent in practice of basic science Intellectual Curiosity/Mechanistic ...
Miller, Rebecca
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tailings From Mining Activities, Impact on Groundwater, and Remediation

Sultan Qaboos University Journal for Science, 2001
Effluent wastes from mining operations and beneficiation processes are comprized mostly of the following pollutants: total suspended solids (TTS), alkalinity or acidity (pH), settleable solids, iron in ferrous mining, and dissolved metals in nonferrous ...
Khalid Al-Rawahy
doaj   +1 more source

Benzobisoxazole cruciforms: a tunable, cross-conjugated platform for the generation of deep blue OLED materials [PDF]

, 2016
Four new cross-conjugated small molecules based on a central benzo[1,2-d:4,5-d′]bisoxazole moiety possessing semi-independently tunable HOMO and LUMO levels were synthesized and the properties of these materials were evaluated experimentally and ...
Cai, Min, Chavez, Ramiro, Jeffries-EL, Malika, Kaudal, Rajiv, Shinar, Joseph, Shinar, Ruth, Tlach, Brian, Tomlinson, Aimee L., Tsyrenova, Ayuna, Wheeler, David L.   +9 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Modeling Flow and Transport in Unsaturated Porous Media: A Review

Sultan Qaboos University Journal for Science, 2000
Underground water is a vital natural resource and every effort should be made to understand ways and means of efficiently using and managing it. The unsaturated zone, bounded at its top by the land surface and below by the water table, is the region ...
H.H. Al-Barwani, M. Al-Lawatia, E. Balakrishnan, A. Purnama   +3 more
doaj   +1 more source

First Steps Toward Change in Teacher Preparation for Elementary Science [PDF]

, 2004
Unless introductory undergraduate science classes for prospective elementary teachers actively incorporate the philosophy of inquiry-based learning called for in K-l2 science education refom little will change in elementary science education.
Daughtrey, T., Fairchild, S., Giovanetti, K., Handley, M., Klevickis, C., Kolvoord, R., Peterson, D.   +6 more
core   +1 more source

Secure Communication Based on Hyperchaotic Chen System with Time-Delay [PDF]

, 2017
This research is partially supported by National Natural Science Foundation of China (61172070, 60804040), Fok Ying Tong Education Foundation Young Teacher Foundation(111065), Innovative Research Team of Shaanxi Province(2013KCT-04), The Key Basic ...
Bai, Chao, Grebogi, Celso, Huang, Zhan-Zhan, Ren, Hai-Peng   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Effect of Wind Environment on the response of Buildings in Oman

Sultan Qaboos University Journal for Science, 1998
An investigation has been carried out to study the effect of the wind parameters on the response of multistory buildings subjected to wind induced forces.
Mohammed Qamaruddin, Salem K. Al-Oraimi
doaj   +1 more source