Results 51 to 60 of about 30,745,353 (308)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Model-Tracing Based Approach to Intelligent Program Diagnosis

open access: yesSultan Qaboos University Journal for Science, 1997
Model-tracing based approach to intelligent program diagnosis and tutoring emphasizes the fact that the student’s design decisions are traced as the students develops the program Systems based on this model monitor the user's actions as the moves along ...
Haider Ali Ramadhan
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Effect of Wind Environment on the response of Buildings in Oman

open access: yesSultan Qaboos University Journal for Science, 1998
An investigation has been carried out to study the effect of the wind parameters on the response of multistory buildings subjected to wind induced forces.
Mohammed Qamaruddin, Salem K. Al-Oraimi
doaj   +1 more source

Science Communication Training: What is Needed for Basic Science and Basic Scientists?

open access: yes, 2023
This report synthesizes the main ideas that emerged in discussions over a two-day workshop hosted by SciPEP (Science Public Engagement Partnership, of the Department of Energy and The Kavli Foundation) that brought together science communication trainers,
Keegan Sawyer   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Calibration of Transit Operations Planning (TOP) Model and Evaluation of Bus Transit Route Performance in Riyadh

open access: yesSultan Qaboos University Journal for Science, 1997
Public transit systems provide mobility for a large percentage of urban residents very cost-effectively and with minimum negative impact on the environment.
P.A. Koushki, G.A. Ali, Y.A. Al-Nuaim
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Experimental Investigation and Failure Analysis of Fastened GRP under Bending Using Finite Element Method and Artificial Neural Networks

open access: yesSultan Qaboos University Journal for Science, 1999
This paper presents a novel approach that predicts the strength and failure modes of jointed Glass Reinforced Polyester (GRP) samples under bending using Finite Element Method (FEM) and Artificial Neural Network (ANN). The mechanical behavior of fastened
C. Seibi Abdennour, M. Al-Alawi
doaj   +1 more source

Fundamentals of Neurogastroenterology: Basic Science [PDF]

open access: yesGastroenterology, 2016
This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version ...
Vanner, S.J.   +6 more
openaire   +4 more sources

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