Results 101 to 110 of about 14,127,790 (305)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Motivation and Attitude of BDS Students and House Officers in Their Postgraduate Career Selection

open access: yesJournal of Islamic International Medical College
Objective: The objective of this research was to explore the motivational factors among BDS students and house officers for post graduate career selection. Study Design: Descriptive cross-sectional study. rd th Place and Duration of Study: The research
Mah Rukh Shahbaz , Fatima Suhaib , Aqib Sohail , Momin Ayub Marath , Herrah Ghaffar Satti , Wardah Ishaque
doaj   +1 more source

U PATHOLOGIST TO OVERSEE HEALTH CENTER\u27S BASIC SCIENCES

open access: yes, 1993
Jerry Kaplan, Ph.D., professor of pathology at the University of Utah School of Medicine, has been named assistant health sciences vice president for basic sciences.

core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

La gestión didáctica del proceso de enseñanza-aprendizaje de las ciencias básicas en las carreras de ingeniería Didactics, teaching and learning sciences at engineering majors [PDF]

open access: yesTransformación, 2017
The process of education of engineering students still shows several weak points. One important shortcoming relates to the application and transfer of basic sciences contents to professional and ordinary life situations.
Gladys Raquel Núñez Lazala
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Basic Products Corporation Wholesale Price List

open access: yes, 1918
After U.S. entry into the war, Hoosier businessmen travelled to Washington to see about procuring war contracts for Indiana industries. The state’s industries furnished war materials on a large scale, their total value approximating $300,000,000.
Basic Products Corporation
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Modeling integration: co-teaching basic and clinical sciences medicine in the classroom

open access: yes, 2018
Joanne M Willey, Youn Seon Lim, Thomas Kwiatkowski Department of Science Education, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA Purpose: Calls for revision in undergraduate medical education frequently cite the ...
Lim YS, Kwiatkowski T, Willey JM
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

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