Results 81 to 90 of about 4,317,506 (277)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The View points of Medical Students In Yazd University of Medical Sciences Toward Horizontal Integration Teaching Method in Anatomical Sciences Courses [PDF]

Strides in Development of Medical Education, 2011
Background & Objective: At present two teaching methods of traditional and integration are used for the theoretical instruction of anatomical sciences including anatomy histology and embryology It is thought that the integration teaching method can help ...
Maryam Dehghan, Morteza Anvari, Mohamad Hosseini Sharifabad, Alireza Talebi, Hossein Nahangi, Abolghasem Abbasi, Sadegh Yadegari   +6 more
doaj  

Towards ontological foundations for agent modeling concepts using UFO [PDF]

, 2005
Foundational ontologies provide the basic concepts upon which any domain-specific ontology is built. This paper presents a new foundational ontology, UFO, and shows how it can be used as a foundation of agent concepts and for evaluating agent-oriented ...
Guizzardi, Giancarlo, Wagner, Gerd
core   +2 more sources

The mathematics of asymptotic stability in the Kuramoto model

, 2018
Now a standard in Nonlinear Sciences, the Kuramoto model is the perfect example of the transition to synchrony in heterogeneous systems of coupled oscillators.
Dietert, Helge, Fernandez, Bastien
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Retention of skull anatomy knowledge in dental education: a comparative study

Frontiers in Dental Medicine
There is limited evidence regarding the retention of essential basic science knowledge among dental students and professionals. Understanding the anatomy of the skull, osteology, is crucial as it provides the structural framework essential for ...
Noora Helene Thune, Noora Helene Thune, Anna Tostrup Kristensen, Anna Tostrup Kristensen, Qalbi Khan, Qalbi Khan, Tor Paaske Utheim, Tor Paaske Utheim, Tor Paaske Utheim, Hugo Lewi Hammer, Amer Sehic, Amer Sehic   +11 more
doaj   +1 more source

Poster: Researchers Say the Darndest Things: Using Semi-structured Interviews to Uncover the Unique Information Behaviors of Basic Sciences Researchers in an Academic Health Center [PDF]

, 2011
Laura discusses the work she and her colleagues did in a qualitative study of semi-structured interviews examining the unique, information-seeking characteristics of basic sciences researchers.
Haines, Laura L
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The value of public health research and the division between basic vs. applied science

Brazilian Journal of Infectious Diseases, 2003
We question the movement towards exclusion of population and social health research from the field of science. The background under analysis is contemporary Brazil, where the scientific field that hosts this kind of research is known as Collective Health.
Almeida-Filho Naomar, Goldbaum Moisés
doaj