Results 61 to 70 of about 4,317,506 (277)

The value of public health research and the division between basic vs. applied science

Brazilian Journal of Infectious Diseases
We question the movement towards exclusion of population and social health research from the field of science. The background under analysis is contemporary Brazil, where the scientific field that hosts this kind of research is known as Collective Health.
Naomar Almeida-Filho, Moisés Goldbaum
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploring cognitive integration of basic science and its effect on diagnostic reasoning in novices

Perspectives on Medical Education, 2016
Integration of basic and clinical science knowledge is increasingly being recognized as important for practice in the health professions. The concept of ‘cognitive integration’ places emphasis on the value of basic science in providing critical ...
Kristina Lisk, Anne M. R. Agur, Nicole N. Woods   +2 more
doaj   +1 more source

Angular Spectra for non-Gaussian Isotropic Fields [PDF]

, 2013
Cosmic Microwave Background (CMB) Anisotropies is a subject of intensive research in several fields of sciences. In this paper we start a systematic development of basic notions and theory in statistics according to the application for CMB.
Terdik, Gyorgy
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Üniversite Adaylarının Temel Bilim Programlarına Yönelik Tercihlerinde Öğretmen Etkisi

İstanbul Eğitim Dergisi
Bu araştırmanın amacı, öğrencilerin üniversite tercihleri sırasında temel bilimleri seçme eğilimlerini etkileyen unsurları ve öğretmenlerin bu süreçteki rolünü incelemektir.
Ayşegül Yazar, Mustafa Sözbilir
doaj   +1 more source

Impact of the COVID-19 Pandemic on Medical Students' Academic Performance in Basic Sciences Period: A Comparative Study at Zahedan University of Medical Sciences [PDF]

Future of Medical Education Journal
Background: The COVID-19 pandemic disrupted traditional medical education, forcing a rapid shift from on-site to online learning and assessment. This study compared the academic performance of medical students in basic sciences period before and during ...
Hossain Bagheri, Narjes Sargolzaei, Saeedeh Sarhadi, Fatemeh Safinataj   +3 more
doaj   +1 more source

Stress among medical students of Gorgan (South East of Caspian Sea), Iran [PDF]

, 2008
Objective: This study aims to estimate the prevalence of psychological stress and association between the levels of stress and study variables among Gorgan medical students.
Alizadeh, F., Gharavi, A.M., Jahanshahi, M., Marjani, A., Vahidirad, A.   +4 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source