Results 51 to 60 of about 14,127,790 (305)

Fundamentals of Neurogastroenterology: Basic Science [PDF]

Gastroenterology, 2016
This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version ...
Vanner, S.J., Greenwood-Van Meerveld, B., Mawe, G.M., Shea-Donohue, T., Verdu, E.F., Wood, J., Grundy, D.   +6 more
openaire   +4 more sources

Ameliorative effect of vanadium on oxidative stress in stomach tissue of diabetic rats [PDF]

, 2014
Between their broad spectrum of action, vanadium compounds are shown to have insulin mimetic/enhancing effects. Increasing evidence in experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of diabetes and
Nuriye Akev, Ayse Can, Refiye Yanardag, Yilmaz-Ozden, Tuğba, Tunali, Sevim, Tugba Yilmaz-Ozden, Ozlem Kurt-Sirin, Sevim Tunali, Akev, Nuriye, Yanardag, Refiye, Kurt-Sirin, Özlem, Can, Ayse, Tunalı, Sevim   +12 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Effect of Covid-19 on Eye Banks and Corneal Transplantations: Current Perspectives

Clinical Ophthalmology, 2022
Francesco Aiello,1 Gabriele Gallo Afflitto,1,2 Giulio Pocobelli,1 Diego Ponzin,3 Carlo Nucci1 1Ophthalmology Unit, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Bascom Palmer Eye Institute, University of Miami ...
Aiello F, Gallo Afflitto G, Pocobelli G, Ponzin D, Nucci C   +4 more
doaj  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Clinical Application of Basic Sciences Courses: Viewpoint of Medical Students at Kermanshah University of Medical Sciences in 2010

آموزش پزشکی, 2014
Background and objective: Educational centers are always facing to basic changes in all levels. Students, as the new workforce making their society’s future, can provide valuable opinions about educational programs and their effects on the learning ...
Ahmad Khoshay, Mari Ataei, Vida Sepahi, Mansuor Rezaei, Sepideh Bakhtiari   +4 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source