Results 91 to 100 of about 34,868 (268)
Two hydrodynamic effects allow strongly nonlinear cochlear response with level-independent admittance [PDF]
This paper discusses the role of 2-D/3-D cochlear fluid hydrodynamics in the generation of the large nonlinear dynamical range of the basilar membrane (BM) and pressure response, in the decoupling between cochlear gain and tuning, and in the dynamic stabilization of the high-gain BM response in the peak region.
arxiv
Quantitative Analysis Linking Inner Hair Cell Voltage Changes and Postsynaptic Conductance Change: A Modelling Study [PDF]
This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to
Drakakis, EM, Prokopiou, AN
core +3 more sources
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Modeling Elasstic Shells Immersed in Fluid [PDF]
We describe a numerical method to simulate an elastic shell immersed in a viscous incompressible fluid. The method is developed as an extension of the immersed boundary method using shell equations based on the Kirchhoff-Love and the planar stress hypotheses. A detailed derivation of the shell equations used in the numerical method is presented.
arxiv
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan+10 more
wiley +1 more source
Non-reflective traveling waves in finite thin beams: A parametric study [PDF]
In the present study, the authors introduce a geometrically improved model inspired by the mammalian basilar membrane's properties and special vibratory behavior while conducting a parametric investigation. The goal of this model is to mimic the broadband non-reflective traveling wave response to excitation frequencies, as observed in the basilar ...
arxiv +1 more source
FPGA Implementation of the CAR Model of the Cochlea [PDF]
The front end of the human auditory system, the cochlea, converts sound signals from the outside world into neural impulses transmitted along the auditory pathway for further processing. The cochlea senses and separates sound in a nonlinear active fashion, exhibiting remarkable sensitivity and frequency discrimination.
arxiv +1 more source
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring+6 more
wiley +1 more source
A silicon model of auditory localization [PDF]
The barn owl accurately localizes sounds in the azimuthal plane, using interaural time difference as a cue. The time-coding pathway in the owl's brainstem encodes a neural map of azimuth, by processing interaural timing information.
Lazzaro, John, Mead, Carver A.
core +1 more source
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke+2 more
wiley +1 more source