Results 101 to 110 of about 1,994,891 (358)

The Development of a Single Frequency Place in the Mammalian Cochlea: The Cochlear Resonance in the Mustached Bat Pteronotus parnellii [PDF]

, 2003
Cochlear microphonic potentials (CMs) were recorded from the sharply tuned, strongly resonant auditory foveae of 1- to 5-week-old mustached bats that were anesthetized with Rompun and Ketavet.
Drexl, Markus, Foeller, Elisabeth, Kössl, Manfred, Russell, Ian J, Vater, Marianne   +4 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Basilar membrane vibration is not involved in the reverse propagation of otoacoustic emissions

Scientific Reports, 2013
To understand how the inner ear-generated sound, i.e., otoacoustic emission, exits the cochlea, we created a sound source electrically in the second turn and measured basilar membrane vibrations at two longitudinal locations in the first turn in living ...
Wenxuan He, T. Ren
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cochlear duct length along the outer wall vs organ of corti: Which one is relevant for the electrode array length selection and frequency mapping using Greenwood function?

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2019
Cochlear duct length (CDL) measurement or estimation is a hot topic for various research groups in the cochlear implant (CI) field as of today. Getting the CDL along the outer wall (LW) and organ of corti (OC) is possible but considering the clinical ...
Anandhan Dhanasingh
doaj   +1 more source

Impact of endolymphatic hydrops on DPOAE in subjects with normal to mild hearing loss

Laryngoscope Investigative Otolaryngology, 2023
Objective The increased endolymph volume affects a shift in the organ of Corti and basilar membrane in ears with endolymphatic hydrops (EH), which might affect distortion‐product otoacoustic emissions (DPOAE) by altering the operating point of the outer ...
Kei Inagaki, Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Yukari Fukunaga, Daisuke Hara, Shinji Naganawa, Michihiko Sone   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

Nature Communications, 2018
The sound envelope is important for speech perception. Here, the authors look at mechanisms by which the sound envelope is encoded, finding that it arises from distortion produced by mechanoelectrical transduction channels.
Alfred L. Nuttall, Anthony J. Ricci, George Burwood, James M. Harte, Stefan Stenfelt, Per Cayé-Thomasen, Tianying Ren, Sripriya Ramamoorthy, Yuan Zhang, Teresa Wilson, Thomas Lunner, Brian C. J. Moore, Anders Fridberger   +12 more
doaj   +1 more source

Time Domain Computation of a Nonlinear Nonlocal Cochlear Model with Applications to Multitone Interaction in Hearing

, 2002
A nonlinear nonlocal cochlear model of the transmission line type is studied in order to capture the multitone interactions and resulting tonal suppression effects.
Deng, Li, Qi, Yingyong, Xin, Jack
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source