Results 61 to 70 of about 27,811 (329)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Morphology and morphometry of the inner ear of the dromedary camel and their influence on the efficiency of hearing and equilibrium

Zoological Letters, 2022
Background The inner ear morphology and size are linked to hearing and balance ability. The goal of this study was to determine the morphology and morphometrics of the dromedary camel's inner ear and how it influences hearing accommodation and ...
Safwat Ali, Abdelraheem Esmat, Atef Erasha, Masahiro Yasuda, Mohamed Alsafy   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Quantitative X-ray tomography of the mouse cochlea. [PDF]

PLoS ONE, 2012
Imaging with hard X-rays allows visualizing cochlear structures while maintaining intrinsic qualities of the tissue, including structure and size. With coherent X-rays, soft tissues, including membranes, can be imaged as well as cells making use of the ...
Christoph Rau, Margaret Hwang, Wah-Keat Lee, Claus-Peter Richter   +3 more
doaj   +1 more source

Oscillation Characteristics of an Artificial Cochlear Sensory Epithelium Optimized for a Micrometer-Scale Curved Structure

Micromachines, 2022
Based on the modern microelectromechanical systems technology, we present a revolutionary miniaturized artificial cochlear sensory epithelium for future implantation tests on guinea pigs.
Hiroki Yamazaki, Yutaro Kohno, Satoyuki Kawano   +2 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Mathematical modeling of cochlear mechanics and disorder

Alexandria Engineering Journal
This paper presents a novel nonlinear multiscale mathematical model that simulates fluid-solid interactions in the cochlea, targeting early diagnosis of sensorineural hearing loss (SNHL).
Nawal H. Siddig, Amal S. Alali
doaj   +1 more source

Mechanical and Electrical Characterization of Piezoelectric Artificial Cochlear Device and Biocompatible Packaging

Sensors, 2015
This paper presents the development of a piezoelectric artificial cochlea (PAC) device capable of analyzing vibratory signal inputs and converting them into electrical signal outputs without an external power source by mimicking the function of human ...
Youngdo Jung, Jun-Hyuk Kwak, Hanmi Kang, Wan Doo Kim, Shin Hur   +4 more
doaj   +1 more source

Adaptation by normal listeners to upward spectral shifts of speech: Implications for cochlear implants [PDF]

, 1999
Multi-channel cochlear implants typically present spectral information to the wrong ''place'' in the auditory nerve array, because electrodes can only be inserted partway into the cochlea.
Faulkner, A, Rosen, S, Wilkinson, L
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source