Results 61 to 70 of about 10,171,924 (292)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hedging price risk under production flexibility and basis risk
, 1999 A également fait l'objet d'une présentation au Southern Risk and Insurance Association, les 21-23/11/1999 à Orlando (USA) Diffusion du document : INRA Unité d'Economie et Sociologie rurales rue Adolphe Bobierre CS 61103 35011 Rennes Cedex (FRA)A ...
Mahul, Olivier +1 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Seismic risk mitigation - the basis of a sustainable development [PDF]
Constructii: Journal of Civil Engineering Research, 2019 The notion of seismic risk is employed to describe the effects of earthquakes on social, economic and environmental aspects over a certain period of time and can be defined as the interaction of three parameters: seismic hazard, exposure time and ...
Aurelia BRADU +3 more
doaj
Measuring and hedging the basis risk by functional data models
, 2012 Actually the longevity phenomenon is a relevant aspect for insurance companies which are obliged to quantify the impact of uncertainty of mortality trend on products issued, in order to manage the risk derived from it.
COPPOLA, MARIAROSARIA +4 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Quadratic Hedging of Basis Risk [PDF]
This paper examines a simple basis risk model based on correlated geometric Brownian motions. We apply quadratic criteria to minimize basis risk and hedge in an optimal manner. Initially, we derive the Follmer-Schweizer decomposition of a European claim.
Hardy Hulley, T. A. McWalter
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source