Results 71 to 80 of about 10,171,924 (292)
Genetic Basis of Familial Cancer Risk: A Narrative Review
DNAFamilial cancers are caused by inherited mutations in specific genes that regulate cell growth, division, and repair. Approximately 5–10% of all cancer cases have a hereditary component, where germline mutations in certain genes increase an individual’s ...
Eman Fares Sabik
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FINANCIAL INFORMATION AS BASIS FOR LIFE INSURANCE RISK MANAGEMENT [PDF]
Zbornik Radova Ekonomskog Fakulteta u Istočnom Sarajevu, 2011 This paper discusses the financialinformation, accurately speaking, their sources andtheir use in the life insurance. The paper points outthe specificity of financial accounting in lifeinsurance as a source of these pieces ofinformation.
Mira Pešić-Andrijić
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Safety Margins for Systematic Biometric and Financial Risk in a Semi-Markov Life Insurance Framework
Risks, 2015 Insurance companies use conservative first order valuation bases to calculate insurance premiums and reserves. These valuation bases have a significant impact on the insurer’s solvency and on the premiums of the insurance products.
Andreas Niemeyer
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Risk and risk perception: the metropolitan imaginary of catastrophe at the time of the Covid-19
, 2021 The Covid-19 health emergency takes place in the list of “new risks” that punctuate the scene of the “world risk society” (Beck, 2011). This state of affairs, characterized by the worsening of the feeling of uncertainty and anguish, finds its raison d ...
Elena SAVONA
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The effectiveness of futures markets as a mechanism for price risk management
Икономика и компютърни наукиThis study explores the utility of futures markets in the agricultural sector, examining their effectiveness in mitigating price risk and their capacity to reflect market fundamentals.
Plamen Penev
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Longevity hedging 101: A framework for longevity basis risk analysis and hedge effectiveness [PDF]
Basis risk is an important consideration when hedging longevity risk with instruments based on longevity indices, since the longevity experience of the hedged exposure may differ from that of the index. As a result, any decision to execute an index-based
Ye, Yijing +6 more
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