Results 81 to 90 of about 1,419,758 (262)
Current perspectives on risk prediction and genetic basis of Brugada syndrome
Frontiers in Cardiovascular MedicineBrugada syndrome (BrS) is an inherited arrhythmia disorder and a major cause of sudden cardiac death below 50 years. Despite more than three decades of research, diagnosis and risk prediction remain challenging due to variable presentation and incomplete
Priya Bhardwaj +7 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Risk Management as a Basis for Integrated Water Cycle Management in Kazakhstan
Journal of Environmental Geography, 2016 Integrated Water Cycle Management (IWCM) aims to bring together a diversity of social, environmental, technological and economic aspects to implement sustainable water and land management systems.
Meyer Burghard +4 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Editorial: Clinical and genetic determinants of diabetes and complications
Frontiers in Endocrinology, 2023 Sen Li +5 more
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Медицина в Кузбассе, 2022 The review is devoted to topical issues of the development of the concept of risk management research as a basis for understanding the reduction of risk events of pharmaceutical organizations.
Андрей Георгиевич Петров +6 more
doaj
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Designing and evaluating a composite climatic index to risk management in livestock insurance
Environmental and Sustainability IndicatorsThe livestock sector in Iran, which has a significant nomadic population, is highly vulnerable to climate change and drought. This high vulnerability increases the need for modern support tools such as insurance, as traditional insurance has proven ...
Mahnaz Kalantaripor +3 more
doaj +1 more source