Results 41 to 50 of about 479,261 (269)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Model development and update of portable NIRS instrument for assessment of internal quality attributes of two navel orange varieties

Frontiers in Nutrition, 2022
The variation of fruit among batches influences the performance of the portable near infrared spectroscopy (NIRS) instrument and then determines the success or failure for practical application in fruit industry. Model development and update methods were
Xudong Sun, Xudong Sun, Di Deng, Jiacheng Liu, Shaoran Feng   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

SEED QUALITY PARAMETERS OF PURPLE HORSEMINT FOR ELABORATION OF STANDART

Овощи России, 2016
Purple horsemint (Monarda citriodora L.) is a perennial plant belonging to Lamiaceae family and being cultivated as aromatic and ornamental crop in many countries of Europe and America. Last years this plant actively gains popularity among gardeners.
L. V. Pavlov, E. V. Baranova, O. T. Paraskova, V. A. Kharchenko, O. V. Bespalko   +4 more
doaj   +1 more source

ILC Based Economic Batch-to-Batch Optimization for Batch Processes

IFAC-PapersOnLine, 2018
Abstract The control strategies for batch processes in the past can be categorized into two levels. The higher level is economic optimization running at low frequency and the lower one tracks the given reference using MPC or PID at the higher level.
Pengcheng Lu, Junghui Chen, Lei Xie
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Variable Batched DGEMM [PDF]

2018 26th Euromicro International Conference on Parallel, Distributed and Network-based Processing (PDP), 2018
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 720270 (HBP SGA1), from the Spanish Ministry of Economy and Competitiveness under the project Computacion de Altas Prestaciones VII (TIN2015-65316-P) and the Departament d’Innovacio, Universitats i Empresa de la ...
Valero-Lara, Pedro, Martinez-Perez, Ivan, Mateo, Sergio, Sirvent Pardell, Raül, Beltran Querol, Vicenç, Martorell Bofill, Xavier, Labarta Mancho, Jesús José   +6 more
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Phenotypic Characterization of Phosphofructokinase Variants in Escherichia coli

Microbiology Research
Phosphofructokinase 1 (PfkA) mediates the ATP-dependent phosphorylation of fructose-6-phosphate and is a key, controlling enzyme in glycolysis for Escherichia coli and other organisms.
Hemshikha Rajpurohit, Mark A. Eiteman
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source