Results 1 to 10 of about 75,023 (258)

Fed-batch bioreactor modeling

SoftwareX
This paper describes an open-source computational tool developed for the modeling and simulation of fed-batch bioreactors, particularly for processes employing Chinese Hamster Ovary (CHO) cells, which are integral to biopharmaceutical manufacturing.
Tilen Gimpelj, Aleksandar Tošić
doaj   +3 more sources

Comparison Between Simple Batch and Fed-Batch Bioreactor Cultivation of Recombinant BCG [PDF]

Pharmaceutics
Background/Objectives: Tuberculosis continues to be a significant global health concern, causing 1.3 million deaths in 2022, particularly affecting children under 5 years old.
Sarah Mendes, Maria C. P. Gonçalves, Vitoria A. P. Aiex, Ryhára D. Batista, Patrícia Zorzete, Luciana C. C. Leite, Viviane M. Gonçalves   +6 more
doaj   +2 more sources

Dissecting cell death pathways in fed-batch bioreactors. [PDF]

Biotechnol J, 2023
AbstractChinese hamster ovary (CHO) cells are widely used for production of biologics including therapeutic monoclonal antibodies. Cell death in CHO cells is a significant factor in biopharmaceutical production, impacting both product yield and quality.
Mentlak DA, Raven J, Moses T, Massie F, Barber N, Hoare R, Burton G, Young A, Pybus LP, Rosser S, White RJ, Ungar D, Bryant NJ.   +12 more
europepmc   +5 more sources

Transferability of bioprocessing modes for recombinant protease production: from fed-batch to continuous cultivation with Bacillus licheniformis [PDF]

BMC Biotechnology
Background Proteases are essential in various industries due to their unique substrate specificities and robustness in different operational conditions.
Stefan Kittler, Fabian Müller, Mohamed Elshazly, Georg Benjamin Wandrey, Tobias Klein, Andreas Daub, Oliver Spadiut, Julian Kopp   +7 more
doaj   +2 more sources

Model-Based Optimization of Fed-Batch In Vitro Transcription. [PDF]

Chembiochem
Recent developments in RNA vaccines and therapeutics have motivated the need for process engineering strategies to optimize the in vitro transcription (IVT) reaction for RNA synthesis. Specifically, practitioners seek to maximize the production of RNA and the incorporation of the 5‐prime cap to the end of each RNA molecule while minimizing the use of ...
Stover NM, Ahmadi S, Rosenfeld J, Destro F, Myerson AS, Braatz RD.   +5 more
europepmc   +3 more sources

Optimization of Culture Media and Feeding Strategy for High Titer Production of an Adenoviral Vector in HEK 293 Fed-Batch Culture [PDF]

Vaccines
Adenoviruses are efficient and safe vectors for delivering target antigens and adenovirus-based vaccines have been used against a wide variety of pathogens, including tuberculosis and COVID-19.
Chun Fang Shen, Anja Rodenbrock, Stephane Lanthier, Elodie Burney, Martin Loignon   +4 more
doaj   +2 more sources

Analysis of biomass productivity and physiology of Nitrososphaera viennensis grown in continuous culture

Frontiers in Microbiology, 2023
Microbial ammonia oxidation is the first and usually rate limiting step in nitrification and is therefore an important step in the global nitrogen cycle. Ammonia-oxidizing archaea (AOA) play an important role in nitrification.
Michael Melcher, Logan H. Hodgskiss, Mohammad Anas Mardini, Christa Schleper, Simon K.-M. R. Rittmann, Simon K.-M. R. Rittmann, Simon K.-M. R. Rittmann   +6 more
doaj   +1 more source

Review: Potensi Tandan Kosong Kelapa Sawit sebagai Bahan Baku Pembuatan Bioetanol dengan Metode Fed Batch pada Proses Hidrolisis

Jurnal Teknik Kimia dan Lingkungan, 2021
Peningkatan kebutuhan energi terutama bahan bakar minyak yang tidak diimbangi dengan ketersediaan sumber energi tak terbarukan akan mengakibatkan kelangkaan energi.
Christyfani Sindhuwati, Asalil Mustain, Yasinta Octaliya Rosly, Andika Soharmat Aprijaya, Mufid Mufid, Ade Sonya Suryandari, Hardjono Hardjono, Sri Rulianah   +7 more
doaj   +1 more source

Screening for optimal protease producing Bacillus licheniformis strains with polymer-based controlled-release fed-batch microtiter plates

Microbial Cell Factories, 2021
Background Substrate-limited fed-batch conditions have the favorable effect of preventing overflow metabolism, catabolite repression, oxygen limitation or inhibition caused by elevated substrate or osmotic concentrations.
Tobias Habicher, Tobias Klein, Jacqueline Becker, Andreas Daub, Jochen Büchs   +4 more
doaj   +1 more source

Continuous fed-batch strategy decreases acetic acid production and increases volatile ester formation in wines under high-gravity fermentation

OENO One, 2023
High sugar fermentation elevates acetic acid levels in wines, which can be avoided by applying the continuous fed-batch strategy. In this study, yeast gene expressions and wine volatile compounds were evaluated by quantitative real-time PCR (RT-qPCR ...
Haixia Deng, Meiyu Wang, Erhu Li
doaj   +1 more source