Results 41 to 50 of about 594,417 (290)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Activation in vesicle-mediated signaling shaped by batch arrival statistics
New Journal of PhysicsVesicle-mediated secretion of ions or molecules is a central mechanism of cellular communication, for example in processes such as neurotransmission or hormone release.
Jan Hauke +2 more
doaj +1 more source
Analysis of Hybrid Buffering and Retransmission in OBS Networks
The Scientific World Journal, 2015 Burst contention is a major problem in the Optical Burst Switching (OBS) networks. Due to inadequate contention resolution techniques, the burst loss is prominent in OBS. In order to resolve contention fiber delay lines, wavelength converters, deflection
D. Veera Vanitha, M. Sabrigiriraj
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Modeling of a Coal Transshipment Complex Based on a Queuing Network
Applied SciencesThis article concerns the problem of estimating the throughput and forecasting the operation of a coal transshipment complex that comprises a marine coal terminal and a railway station. Scenario modeling is employed to address this issue.
Alexander Kazakov +2 more
doaj +1 more source
A novel method for generating the optimal routing matrix of queuing networks with batch service [PDF]
Известия Саратовского университета. Новая серия: Математика. Механика. ИнформатикаIn this paper, we consider a large-scale open queuing network. The arrival process in the queueing network is Poissonian. Сustomer transitions between nodes are described by the routing matrix.
Sergeeva, Nadezhda Viktorovna +3 more
doaj +1 more source
Effect of Farm Management Practices on Morbidity and Antibiotic Usage on Calf Rearing Farms
Antibiotics, 2022 Antimicrobial resistance has been recognized as one of the top health threats to human society. Abundant use of antibiotics in both humans and animals has led to ever-increasing antibiotic resistance in bacteria.
Atte Sandelin +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
MathematicsThis research investigated a single bulk server queuing model where service modes and server vacations are dependent on the number of clients. The server operates in three different service modes: single service, fixed batch service, and variable batch ...
Subramani Palani Niranjan +2 more
doaj +1 more source