Results 31 to 40 of about 22,244 (218)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

High-quality development path for methanol and reconfiguration of its storage and transportation system driven by the “dual carbon” goals

You-qi chuyun
ObjectiveAmid the “carbon peaking and carbon neutrality” strategy and energy structure transformation, China faces challenges such as new energy power consumption hurdles and low utilization rates of traditional oil and gas pipelines.
Shangxin ZHAO
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Current status and prospects of technological development for batch transportation of methanol via product oil pipelines

You-qi chuyun
ObjectiveWith the accelerated implementation of carbon peaking and carbon neutrality strategies, the consumption mix of traditional oil and gas resources has undergone significant changes, reflected in a slowing growth rate of oil and gas demand and a ...
Weibin WANG, Kuirong LIU, Yuxing LI
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analytic Research on Adaptability of Key Equipment for Sequential Methanol Transportation in Product Oil Pipelines

You-qi chuyun
[Objective] Some refined oil pipelines in China operate at low load rates. Utilizing these pipelines for batch transportation of methanol not only supports long-distance, large-scale methanol storage and transportation, but also maximizes pipeline asset ...
Cailin WANG, Ziqiang GU, Shujuan QIU, Xiaolong LI, Jingfa LI, Bo YU, Yuxing LI, Xinran YU   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Transient flow and mixed oil characteristics of the methanol-refined oil batch transportation

You-qi chuyun
ObjectiveBatch transportation of methanol through existing refined oil pipelines enhances transportation efficiency, reduces costs, and addresses challenges in hydrogen energy storage and transportation.
Wen YANG, Shangsheng HUANG, Pengbo YIN, Feng YAN, Xin HUANG, Jiaqing LI, Shihang RAO, Lin TENG   +7 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Applicability analysis of mixed oil length simulation using OLGA software for methanol-diesel batch transportation

You-qi chuyun
ObjectiveIncorporating methanol transport into refined oil pipelines can address the declining throughput of these pipelines while providing a safer transportation route for liquid hydrogen energy.
Diwu CHEN, Bohui SHI, Feng YAN, Jing GONG, Yubin WANG, Kai WEN, Zhengbing LI   +6 more
doaj   +1 more source