Results 251 to 260 of about 182,508 (303)
Characterisation of the Bax-nucleophosmin interaction: the importance of the Bax C-terminus
Apoptosis, 2008 The molecular chaperone nucleophosmin has been identified as a novel Bax binding protein with this interaction proposed to be a key event in the activation and translocation of Bax in mitochondrial dysfunction and apoptotic cell death. Using a proximity assay, we have quantitatively defined the high affinity and saturable interaction between Bax and ...
Thompson, Jane +6 more
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Biochimie, 2011
The pro-apoptototic protein Bax (Bcl-2 Associated protein X) plays a central role in the mitochondria-dependent apoptotic pathway. In healthy mammalian cells, Bax is essentially cytosolic and inactive. Following a death signal, the protein is translocated to the outer mitochondrial membrane, where it promotes a permeabilization that favors the release ...
Thibaud T, Renault, Stéphen, Manon
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The pro-apoptototic protein Bax (Bcl-2 Associated protein X) plays a central role in the mitochondria-dependent apoptotic pathway. In healthy mammalian cells, Bax is essentially cytosolic and inactive. Following a death signal, the protein is translocated to the outer mitochondrial membrane, where it promotes a permeabilization that favors the release ...
Thibaud T, Renault, Stéphen, Manon
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BAXing in the hypersensitive response
Trends in Plant Science, 1999Most of the cell death pathways that have been characterized in animal systems require caspase activation as a deterministic step. In some cases, this might involve mitochondria participation, whereas others by-pass this organelle and activate caspases using protein–protein interactions. In organisms such as C.
, Lam, , del Pozo O, , Pontier
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Characterization of Bax-ς, a Cell Death-Inducing Isoform of Bax
Biochemical and Biophysical Research Communications, 2000The Ced-9/Bcl-like family of genes codes for proteins that have antiapoptotic and proapoptotic activity. Several Bax isoproteins have been detected by 2-D gel electrophoresis, and a novel human member, designated as Bax-sigma, has been identified and cloned from human cancer promyelocytic cells. Bax-sigma contains BH-3, BH-1, and BH-2 domains, putative
E, Schmitt +4 more
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Science's STKE, 2000
Many anticancer agents kill tumor cells by inducing apoptosis, and improvements in therapeutic strategies will depend on a clear understanding of the molecular mechanisms by which this occurs. To study the role of the Bax protein in drug-induced apoptosis, Zhang et al. used sophisticated genetic approaches to create
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Many anticancer agents kill tumor cells by inducing apoptosis, and improvements in therapeutic strategies will depend on a clear understanding of the molecular mechanisms by which this occurs. To study the role of the Bax protein in drug-induced apoptosis, Zhang et al. used sophisticated genetic approaches to create
+4 more sources
Science's STKE, 2004
Apoptosis-associated speck-like protein (ASC) is inactivated in about 40% of breast cancers. Its expression is induced in response to the tumor suppressor protein p53 and to DNA damage. Ohtsuka et al. have now identified a p53-binding sequence in promoter of the ASC gene.
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Apoptosis-associated speck-like protein (ASC) is inactivated in about 40% of breast cancers. Its expression is induced in response to the tumor suppressor protein p53 and to DNA damage. Ohtsuka et al. have now identified a p53-binding sequence in promoter of the ASC gene.
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Proceedings of the Royal Musical Association, 1977
On 27 July 1913 Colin Taylor, a music master at Eton and confidant of the young Philip Heseltine, wrote to his protégé: By the way I was introduced to Bax at the Russian Ballet the other night – do you know him? I have always pictured him as a slow speaking dreamy man – dreamy he may be, but in his speech he is short, dry and quite unpoetical.
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On 27 July 1913 Colin Taylor, a music master at Eton and confidant of the young Philip Heseltine, wrote to his protégé: By the way I was introduced to Bax at the Russian Ballet the other night – do you know him? I have always pictured him as a slow speaking dreamy man – dreamy he may be, but in his speech he is short, dry and quite unpoetical.
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Physiological and pharmacological modulation of BAX
Trends in Pharmacological Sciences, 2022Evripidis Gavathiotis
exaly