Results 111 to 120 of about 320,112 (306)

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

Gyejibongnyeong-Hwan (Gui Zhi Fu Ling Wan) Ameliorates Human Uterine Myomas via Apoptosis

Frontiers in Pharmacology, 2019
Uterine leiomyomas are the most common benign neoplasms in women of reproductive age. However, non-surgical treatments for uterine myomas have not been fully evaluated.
So Min Lee, Eun Som Choi, Eun Som Choi, Eunyoung Ha, Kon Young Ji, So Jin Shin, Jeeyoun Jung   +6 more
doaj   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Lauric Acid’s Potential as an Apoptotic Agent in Oral Cancer: Unravelling the Mechanism through an In vitro Analysis

Biomedical and Biotechnology Research Journal
Background: The effects of lauric acid (LA) on various human cancer cell types have been explored, yet there remains a paucity of research focused specifically on its influence in the context of oral cancer (OC).
Kirti B. Buva, Ajinkya A Deshmukh, Shreya Manohar Hiwalkar, Gauri Mansinh Kumbhar, Vaibhav Sunil Ladke   +4 more
doaj   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Effect of Aspartam on histomorphometric alterations, kidney function and expression of Bcl2, Bax, Caspase 3, P53 Genes in Mice

مجله دانشگاه علوم پزشکی گرگان, 2021
Background and Objective: Aspartame is a kind of artifical and non-sugar sweetener that is used as a sugar substitute in some foods and beverages. This study was done to determine effect of Aspartam on histomorphometric alterations, kidney function and ...
Narges Zadsar, Hassan Morovvati, Zahra Tootian, Mohammadtaghi Sheybani, Mohammad Taheri, Hojat Anbara   +5 more
doaj  

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Alkaloid fraction of Achyranthes aspera Linn triggers breast cancer apoptosis in mice (Mus musculus) model

Open Veterinary Journal
Background: Breast cancer affects women at various ages, and its recurrence is a significant cause of death. The search for potent anticancer compounds of herbal origin with well-defined mechanisms of action is an essential focus of current research ...
Wurlina Wurlina, Dewa Ketut Meles, Imam Mustofa, Aswin Rafif Khairullah, Dewa Made Sucipta Putra, Niluh Suwasanti, Adeyinka Oye Akintunde, Suzanita Utama, Sri Mulyati, Wasito Wasito, Ricadonna Raissa, Riza Zainuddin Ahmad, Julaeha Julaeha, Fitrine Ekawasti   +13 more
doaj   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source