Results 91 to 100 of about 320,112 (306)

Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

Diagnostic Pathology, 2012
Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice, Yenicesu GoncaImir, Arici Sema, Cetin Meral, Tuncer Ersin, Cetin Ali   +5 more
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Mitochondrial apoptosis induced by Chamaemelum nobile extract in breast cancer cells [PDF]

, 2016
Chamaemelum nobile (Asteraceae) commonly known as ‹Roman chamomile› is a medicinal plant used for numerous diseases in traditional medicine, although its anticancer activity is unknown.
Amanzadeh, A., Kandelous, H.M., Khuri, V., Rastkari, N., Salimi, M., Salimi, M.   +5 more
core  

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
A Bobba, A Brunet, A Lipkin, A Reymond, AP Aalto, B Pettmann, CM Knudson, CM Pickart, DA Cross, DA Cross, DA Linseman, DP Martin, E Towers, F Jaudon, G Lutfalla, G Meroni, GV Putcha, I Lassot, I Robbins, J Gilley, J Ham, J Ham, J Whitfield, J Yuan, JX Comella, KA Wood, L Swainson, L Vanhille, M Broemer, M Kristiansen, M M Magiera, M Sardiello, MH Glickman, N Canu, R Bhat, R Rahmeh, R Sadoul, RJ Youle, S Desagher, S Desagher, S Mora, S Ogawa, SJ Riedl, SJ Thompson, SR D'Mello, SR Datta, T Urano, TM Miller, TM Miller, V Arce, V Hongisto, Y Du, Z Xia   +52 more
core   +5 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link [PDF]

, 2011
The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing
Fulda, Simone
core   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Technological development, structural unemployment and social exclusion in the Netherlands [PDF]

This paper introduces a general, formal treatment of dynamic constraints, i.e., constraints on the state changes that are allowed in a given state space.
Bax, E.H.
core   +1 more source

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent [PDF]

, 2008
A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the ...
A. BORRELLI, A. MANCINI, A. SCHIATTARELLA, D. PAGNOZZI, F. MORELLI, GRIECO, PAOLO, J. ROMMELAERE, L. ALOJ, LORIZIO, ROBERTO, M. AURILIO, MAZZARELLA, LELIO, NOVELLINO, ETTORE, OCCHIELLO, ANTONELLA, PICA, ALESSANDRA, PUCCI, PIETRO, R. MANCINI, SICA, ALESSANDRO, SICA, FILOMENA   +17 more
core   +2 more sources

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source