Results 81 to 90 of about 320,112 (306)

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]

, 2013
It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren, Seddon, Benedict, Sinclair, Charles, Yates, Andrew J.   +3 more
core   +1 more source

BAX-Dependent and BAX-Independent Regulation of Kiss1 Neuron Development in Mice [PDF]

Endocrinology, 2010
The Kiss1 gene and its product kisspeptin are important regulators of reproduction. In rodents, Kiss1 is expressed in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV)/rostral periventricular (PeN) nuclei. In the AVPV/PeN, females have more Kiss1 and tyrosine hydroxylase (TH) neurons than males.
Sheila J, Semaan, Elaine K, Murray, Matthew C, Poling, Sangeeta, Dhamija, Nancy G, Forger, Alexander S, Kauffman   +5 more
openaire   +2 more sources

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Escherichia coli induces apoptosis and proliferation of mammary cells [PDF]

, 2001
Mammary cell apoptosis and proliferation were assessed after injection of Escherichia coli into the left mammary quarters of six cows. Bacteriological analysis of foremilk samples revealed coliform infection in the injected quarters of four cows.
AD Metcalfe, AJ Bramley, AV Capuco, AV Capuco, AW Hill, AW Hill, B Zavizion, BR Rueda, C Kampf, C Legrand, CA Wesson, CB Thompson, CM Alexander, CR Roh, DA Siwik, DE Shuster, DE Shuster, GM Swank, GR Merlo, H Heermeier, JM Adams, JS Hogan, K Schorr, K Schorr, KB Reddy, KR Matthews, KW Bayles, LA Rudolph-Owen, LG Sheffield, LR Lund, M Colitti, M Li, M Li, ME Burow, MM Keane, N Boudjellab, N Boudreau, NA Thornberry, NR Keller, P Maloof, PA Furth, R Blowey, R Strange, RB Hazan, RJ Eberhart, RJ Eberhart, S Ohta, S Pullan, T Tanaka, UK Mebmer, VC Farr, X Li, YJ Tzeng   +52 more
core   +2 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Prognostic implications of left ventricular global longitudinal strain in heart failure patients with narrow QRS complex treated with cardiac resynchronization therapy: a subanalysis of the randomized EchoCRT trial [PDF]

, 2016
Aim: Left ventricular (LV) global longitudinal strain (GLS) reflects LV systolic function and correlates inversely with the extent of LV myocardial scar and fibrosis.
Abraham, William T., Bax, Jeroen J., Borer, Jeffrey S., Brugada, Josep, Delgado, Victoria, Dickstein, Kenneth, Ford, Ian, Gorcsan, John, Gras, Daniel, Holzmeister, Johannes, Krum, Henry, Robertson, Michele, Ruschitzka, Frank, Singh, Jagmeet P., Sogaard, Peter   +14 more
core   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

INHIBITION OF CELLULAR INVASION AND INDUCTION OF ANOIKIS IN MOUSE MELANOMA CELLS BY AN ANTI-INFLAMMATORY AGENT DTCM-GLUTARIMIDE

Креативная хирургия и онкология, 2017
Previously, we designed DTCM-glutarimide as a novel anti-inflammatory agent inhibiting macrophage activation. It also showed anti-inflammatory activity in vivo.
A. Kaneda, Sh. Kh. Gantsev, K. Umezawa
doaj   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Effect of aerobic exercise on some factors of cardiac apoptosis in male rats

Fiyz̤, 2019
Background: Cardiac apoptosisplays an important role in myocardial diseases. Current evidence suggests that exercise training may modify some apoptosis-related signaling in myocardium.
Sadighi A , Abdi A , Azarbayjani MA , Barari AR   +3 more
doaj