Results 71 to 80 of about 320,112 (306)

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100

Biomedicines, 2020
The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of two DNA plasmids encoding genetic sequences of the apoptosis-inducing molecule, BAX, and the secreted form of the autoantigen, glutamic
David G. Alleva, Melika Rezaee, Linda Yip, Gang Ren, Jarrett Rosenberg, Waldo Concepcion, Alan Escher, Shahrokh Shabahang, Avnesh S. Thakor   +8 more
doaj   +1 more source

Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]

Journal of Genetic Resources, 2016
Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari, Madjid Momeni-Moghaddam, Faris Farassati, Abolfazl Rad   +3 more
doaj   +1 more source

Policy and Practice: Customer Service in Illinois Department of Human Services Local Offices [PDF]

, 2003
In a single month, as many as 6,400 to 12,500 people visit each of the busiest of the Illinois Department of Human Services (IDHS) local offices. Since welfare reform in 1996, TANF caseloads in Illinois have declined precipitously.
Elizabeth Bax, Lise McKean
core  

RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells [PDF]

, 2008
The balance between antiapoptotic and proapoptotic proteins of the Bcl-2 family is critical in determining the fate of T cells in response to death stimuli.
A., Annibaldi, A., Costanzo, B., Marinari, Levrero, Massimo, Muscolini, Michela, R., Cianfrocca, Tuosto, Loretta, V., Marzano   +7 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Follow-up study of expression of Bcl-2, Bax, p53 and ACE in CD34+ cells of peripheral blood and bone marrow in acute leukemia patients in the course of induction chemotherapy

Терапевтический архив, 2011
Aim. To determine unbalance in the system of programmed cell death in the cells CD34+ of the bone marrow (BM) and peripheral blood (PB) before and after cytostatic impact in acute leukemia (AL). Material and methods.
Elena Evgen'evna Khodunova, Elena Nikolaevna Parovichnikova, Irina Vladimirovna Gal'tseva, Sergey Mikhaylovich Kulikov, Valentin Grigor'evich Isaev, Valeriy Grigor'evich Savchenko, E E Khodunova, E N Parovichnikova, I V Galtseva, S M Kulikov, V G Isaev, V G Savchenko   +11 more
doaj  

The expression of VDACs and Bcl2 family genes in pituitary adenomas: clinical correlations and postsurgical outcomes

Frontiers in Endocrinology
IntroductionPituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely understood at the molecular level.
AN Facundo, AN Facundo, AN Facundo, M Magalhães, GC Nascimento, GC Nascimento, RS Azulay, RS Azulay, RM Santos, LA Freitas, AGPAC Nascimento, AGPAC Nascimento, VP Rodrigues, VP Rodrigues, WC Santos, WC Santos, AMGS Beckman, JMF Abreu, JMF Abreu, RP Silva, EL Carneiro, CP Oliveira Neto, CP Oliveira Neto, RM Gil da Costa, RM Gil da Costa, RM Gil da Costa, R Corcoy, R Corcoy, E Mato, E Mato, MS Faria, MS Faria, MS Faria   +32 more
doaj   +1 more source

Effects of carfilzomib alone and in combination with cisplatin on the gene expression of Bcl-2 and Bax in ovarian carcinoma cell lines [PDF]

Journal of Preventive and Complementary Medicine
Background: Carfilzomib (CFZ), a proteasome inhibitor, has demonstrated potential in the treatment of ovarian cancer, including variants that are resistant to cisplatin (Cis).Objectives: This study aims to evaluate the effects of CFZ, both as a ...
Alireza Saedi, Javad Zavar Reza, Navid Ghasemzadeh, Moein Moradi, Behnaz Majidi, Amir Hossein Fatehi Marj, Sadegh Zarei   +6 more
doaj   +1 more source

The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells [PDF]

Avicenna Journal of Medical Biochemistry, 2019
Background: Resveratrol (RezV) which is found in several plants including grapes and types of berries has a vital role in inducing apoptosis and suppressing cell proliferation.
Nooshin Shabab, Saeid Afshar, Massoud Saidijam   +2 more
doaj   +1 more source