Results 121 to 130 of about 182,508 (303)

Covalent Inhibition of Pro-Apoptotic BAX

, 2023
BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively.
McHenry, Matthew William
core  

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

Curcumin Induces Bax Translocation.

, 2013
Fibroblasts were seeded on diagnostic microscope slides and treated with 25 µM curcumin, 500 µM DIDS, the combination, or were left untreated. After 24 hours, cells were fixed and permeabilized and subsequently stained using a specific Ab against Bax A,D,
Frans G. M. Russel (225673), Frank A. D. T. G. Wagener (207559), Sebastiaan W. C. Pennings (371013), Henricus A. M. Mutsaers (225665), Alwin Scharstuhl (371012)   +4 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Allosteric Sensitization of Pro-Apoptotic BAX

, 2018
BAX is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation ...
Wales, Thomas E., Cohen, Daniel, Engen, John R., Luccarelli, James, Wachter, Franziska, Lee, Susan, Heffron, Gregory, Coote, Paul, Pritz, Jonathan R., Massefski, Walter, Walensky, Loren   +10 more
core   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

In Vitro Activity of Citrus IntegroPectin Against Breast Cancer and Colon Cancer

ChemFoodChem, EarlyView.
Image shows microscopic photographs of MCF‐7 cells in the presence of lemon, red orange, and sweet orange IntegroPectin bioconjugates at 0.5 or 1.0 mg/mL concentration after 24 h next to a photograph of MCF‐7 cells as such (control). ABSTRACT We investigate the ability of IntegroPectin bioconjugates obtained via acoustic cavitation of lemon, red orange,
Claudia D'Anna, Caterina Di Sano, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna, Mario Pagliaro   +5 more
wiley   +1 more source

CHARACTERIZATION OF A NOVEL TUMOR SUPPRESSOR BAX

, 2013
Bax is a pro-death tumor suppressor. The loss of functional Bax expression can enhance the tumor growth. Recently we discovered a new family of functional Bax isoforms generated specifically in certain tumors; one of them is Bax 2 .
Wang, Xin
core  

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source