Results 11 to 20 of about 145,032 (262)
Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax [PDF]
Experimental Biology and Medicine, 2019 Bax is an essential mediator of mitochondria-dependent programed cell death. Bax belongs to the Bcl-2 family of proteins and its activities are regulated through interaction with other member proteins in the Bcl-2 family. To date, several apoptosis-inducing drugs activating Bax have been developed, and some of them are already in the market as ...
Kelsey, Jensen +4 more
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Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax
Frontiers in Oncology, 2023 The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that, in cellulo, the substitution of S184 by a non-phosphorylatable residue stimulates both the mitochondrial localization of ...
Lilit Simonyan +10 more
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Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
Czech Journal of Animal Science, 2013 Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture.
M. Sedmíková +7 more
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Kinetic Study of Reaction between Allyl Compounds of Mg and Ethylene: Computational Investigation [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2017 The reactions of propenyl magnesium halides with ethylene were studied using ab initio calculations. The structure of the transition state and the ground state were evaluated and obtained the structural properties, theoretical thermodynamic and kinetic ...
Elahe Rajaeian, Avat (Arman) Taherpour
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Effect of N-acetyl cysteine on oxidative stress and Bax and Bcl2 expression in the kidney tissue of rats exposed to lead [PDF]
The Ukrainian Biochemical Journal, 2021 This study aimed to consider the lead-induced oxidative damage of the kidney of male rats and the role of antioxidant N-acetylcysteine (NAC) in preserving cells against Pb toxicity.
M. Gholami +4 more
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4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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Two Targets, One Hit: new Anticancer Therapeutics to Prevent Tumorigenesis Without Cardiotoxicity
Frontiers in Pharmacology, 2021 A serious adverse effect of cancer therapies is cardiovascular toxicity, which significantly limits the widespread use of antineoplastic agents. The promising new field of cardio-oncology offers the identification of potent anti-cancer therapeutics that ...
Zoltán Szabó +4 more
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Apoptosis status and proliferative activity in mucopolysaccharidosis type I mice tongue mucosa cells
Dental Research Journal, 2012 Background: Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of alfa-iduronidase (IDUA), which leads to intralysosomal accumulation of glysosaminoglycans.
Juliana Noguti +5 more
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Journal of Cell Biology, 2009 The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol.
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Frontiers in Future TransportationIntroductionSeveral plans have been announced recently to reduce emissions, with a focus on climate change. Current methods for creating attractive and sustainable transport take a broader perspective, including transport-related emissions and noise, but
Sven Borén, Henrik Ny, Juliette Tenart
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