Results 211 to 220 of about 298,121 (314)

Genetic Variability in Cisplatin Metabolism in Kidney Injury in Patients With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiotherapy

Head &Neck, EarlyView.
ABSTRACT Background This study investigated the roles of single nucleotide variants (SNVs) in genes of CDDP metabolism and their association with kidney dysfunction in patients with head and neck squamous cell carcinoma (HNSCC). Methods A total of 109 patients with locally advanced HNSCC, treated with CDDP, had renal function evaluated by serum ...
Ericka Francislaine Dias Costa, Ana Maria Castro Ferreira, Marilda Mazzali, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima   +4 more
wiley   +1 more source

Burdock Fructooligosaccharide Protects Against Diabetic Nephropathy in Mice by Regulating Nrf2 Signaling. [PDF]

Pharmacol Res Perspect
Zhu L, Ding M, Liu L, Yuan P, Shao T, Liu C, Xi C, Han J, Zhou Y, Zhang D, Wang G.   +10 more
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Piperlongumine mediated apoptosis in cervical cancer cells beyond docking predictions. [PDF]

Toxicol Rep
Parveen S, Ahtsham A, Kumar S, Gupta P, Ghous F, Banerjee M.   +5 more
europepmc   +1 more source

Apoptosis regulators of the Bcl‐2 family play a key role in chemoresistance of cholangiocarcinoma organoids

International Journal of Cancer, EarlyView.
What's New? Poor prognosis in cholangiocarcinoma (CCA) is attributed to late diagnosis and intrinsic chemoresistance. In particular, resistance mechanisms that suppress apoptosis limit the effectiveness of gemcitabine‐based regimens, which remain the standard treatment.
Wunan Mi, Gilles S. van Tienderen, Shaojun Shi, Amy Broeders, Kathryn Monfils, Henk P. Roest, Luc J. W. van der Laan, Monique M. A. Verstegen   +7 more
wiley   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

Alterations in apoptotic pathways and expression of miR-134, miR-181, and miR-497 induced by Wharton's jelly-derived mesenchymal stem cells in a rat model of ischemic brain injury. [PDF]

IBRO Neurosci Rep
Alizamir T, Jouzdani AF, Attari F, Arab L, Ashaari Z, Komaki A, Hassanzadeh G.   +6 more
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Multifunctional Mesoporous Titanium Dioxide Nanodrug for Corneal Haze Treatment and Its Mechanism. [PDF]

Biomater Res
Li T, Wu X, Huang Y, Tang J, Zhang Y, Du Y, Du Z.   +6 more
europepmc   +1 more source

Toxicological Response of the BEAS‐2B Cell After Acute Exposure at the Air–Liquid Interface to Ethylbenzene and m‐Xylene Alone and in Binary Mixtures

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzene, toluene, ethylbenzene, and xylenes (o‐, m‐, and p‐xylenes) constitute a family, named BTEX, of volatile organic compounds (VOCs) known for its toxicity. This study aimed to study the acute in vitro toxicity of ethylbenzene and m‐xylene on human bronchial epithelial cells exposed at the air–liquid interface (ALI).
Nour Jaber, Claude Emond, Fabrice Cazier, Sylvain Billet   +3 more
wiley   +1 more source