Results 221 to 230 of about 150,507 (294)

BMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced Cardiotoxicity. [PDF]

Pharmaceuticals (Basel)
Rolando JM, Singla DK.
europepmc   +1 more source

Identification of BCL2L11 as a Candidate Gene for Hereditary Predisposition to Non‐Medullary Thyroid Cancer Using Familial Whole‐Exome‐Sequencing

Clinical Genetics, EarlyView.
Whole‐exome sequencing of five families with non‐medullary thyroid cancer revealed three candidate genes. Functional analyses confirmed BCL2L11 as a strong candidate gene for hereditary predisposition to non‐medullary thyroid cancer. ABSTRACT Familial non‐medullary thyroid cancer, defined as two or more affected first‐degree relatives, accounts for 3 ...
Duygu Abbasoglu, Mathis Lepage, Nicolas Sonnier, Sandrine Viala, Nancy Uhrhammer, Flora Ponelle‐Chachuat, Anne Cayre, Maud Privat, Mathias Cavaillé, Yannick Bidet   +9 more
wiley   +1 more source

AMPK Limits MNNG-Induced Parthanatos by Inhibiting BH3-Only Protein Bim. [PDF]

Int J Mol Sci
Hamano S, Maruyama T, Suzuki M, Mitsuya M, Yokosawa T, Hirata Y, Matsuzawa A, Noguchi T.   +7 more
europepmc   +1 more source

FAM20B Related Skeletal Dysplasia: Expanding the Prenatal Phenotype

Clinical Genetics, EarlyView.
FAM20B encodes glycosaminoglycan xylosylkinase, a key enzyme in proteoglycan biosynthesis. We report compound heterozygous FAM20B variants causing severe, lethal skeletal dysplasia in three fetuses from two pregnancies. Disrupted glycosaminoglycan chain formation leads to abnormal cartilage and bone development, illustrating the essential role of ...
Arda Arduç, Linda C. Zuurbier, Merel C. van Maarle, Peter Lauffer, Jonathan I. M. L. Verbeke, Caroline J. Bax, Minke van Tuyl, Ron Hochstenbach, Eva Pajkrt   +8 more
wiley   +1 more source

The Potential Protective Effects of EGCG Against Epilepsy-Induced Damage in Rats by Mitigating Oxidative Stress, Inflammation, and Apoptosis. [PDF]

Scientifica (Cairo)
Alatawi S, Albalawi MS, Alfaifi RM, Al-Twalhy R, Al-Johani MD, Alanazi D, Al-Otaibi RM, Hassan HM, Al-Gayyar MMH.   +8 more
europepmc   +1 more source

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

Cell Proliferation, EarlyView.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen   +9 more
wiley   +1 more source

Identifying the Key Mitochondria-Related Genes in COPD by Integrating Machine Learning and Bioinformatics Analyses. [PDF]

Int J Genomics
Qu J, Zhang M, Hu Y, Yang G, Zhang X, Zhang W, Qu Y.   +6 more
europepmc   +1 more source

Optical Properties of Micro-Pulling Down Method Grown Nd3+:(La1-x,Bax)F3-x as Potential Vacuum Ultraviolet Laser Material and Scintillator

, 2008
Yusuke Furukawa, Marilou Cadatal‐Raduban, Young-Seok Seo, Shingo Ono, Elmer Estacio, Hidetoshi Murakami, Yasushi Fujimoto, Nobuhiko Sarukura, Masahiro Nakatsuka, Kentaro Fukuda, Rayko Simura, Toshihisa Suyama, Akira Yoshikawa   +12 more
openalex   +2 more sources

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

High Doses of Norfloxacin Nicotinate Induce Apoptosis, Developmental Neurotoxicity, and Aberrant DNA Methylation in Zebrafish (<i>Danio rerio</i>) Larvae. [PDF]

Animals (Basel)
Fang H, Wang R, Wang F, Li K, Liang H, Su T, Wei L, Ruan J, Li F, Liang X.   +9 more
europepmc   +1 more source