Results 261 to 270 of about 150,507 (294)
Some of the next articles are maybe not open access.
HDAC–Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells
Journal of Medicinal Chemistry, 2020Inspired by the synergistic effect of BTSA1 (a Bax activator) and SAHA (a histone deacetylase (HDAC) inhibitor) in HeLa cell growth suppression, a series of novel HDAC-Bax multiple ligands were designed rationally. Compound 23, which possesses similar HDAC inhibitory activity relative to SAHA and Bax affinity comparable to BTSA1, exhibits a superior ...
Tao Liang +5 more
openaire +2 more sources
Biochimie, 2011
The pro-apoptototic protein Bax (Bcl-2 Associated protein X) plays a central role in the mitochondria-dependent apoptotic pathway. In healthy mammalian cells, Bax is essentially cytosolic and inactive. Following a death signal, the protein is translocated to the outer mitochondrial membrane, where it promotes a permeabilization that favors the release ...
Thibaud T, Renault, Stéphen, Manon
openaire +2 more sources
The pro-apoptototic protein Bax (Bcl-2 Associated protein X) plays a central role in the mitochondria-dependent apoptotic pathway. In healthy mammalian cells, Bax is essentially cytosolic and inactive. Following a death signal, the protein is translocated to the outer mitochondrial membrane, where it promotes a permeabilization that favors the release ...
Thibaud T, Renault, Stéphen, Manon
openaire +2 more sources
Characterization of Bax-ς, a Cell Death-Inducing Isoform of Bax
Biochemical and Biophysical Research Communications, 2000The Ced-9/Bcl-like family of genes codes for proteins that have antiapoptotic and proapoptotic activity. Several Bax isoproteins have been detected by 2-D gel electrophoresis, and a novel human member, designated as Bax-sigma, has been identified and cloned from human cancer promyelocytic cells. Bax-sigma contains BH-3, BH-1, and BH-2 domains, putative
E, Schmitt +4 more
openaire +2 more sources
Bax. The pro-apoptotic Bcl-2 family member, Bax.
The international journal of biochemistry & cell biology, 1998Bax is a pro-apoptotic member of the Bcl-2 family of genes which regulate programmed cell death. The Bax protein shares highly conserved domains with Bcl-2, some of which are required for the formation of Bax-Bcl-2 heterodimers. Bax expression is elevated in certain tissues after apoptotic stimuli and can be directly regulated by p53. Bax -/- mice have
H J, Brady, G, Gil-Gómez
openaire +1 more source
Science's STKE, 2007
At about age 50, depletion of ovarian follicles through apoptosis leads to the loss of cyclic ovarian function in women. Menopause, in turn, is believed to set the stage for various health problems. Although aging female mice do not undergo menopause, they experience depletion of ovarian follicles and health complications similar to those ...
openaire +1 more source
At about age 50, depletion of ovarian follicles through apoptosis leads to the loss of cyclic ovarian function in women. Menopause, in turn, is believed to set the stage for various health problems. Although aging female mice do not undergo menopause, they experience depletion of ovarian follicles and health complications similar to those ...
openaire +1 more source
Science's STKE, 2004
Apoptosis-associated speck-like protein (ASC) is inactivated in about 40% of breast cancers. Its expression is induced in response to the tumor suppressor protein p53 and to DNA damage. Ohtsuka et al. have now identified a p53-binding sequence in promoter of the ASC gene.
openaire +1 more source
Apoptosis-associated speck-like protein (ASC) is inactivated in about 40% of breast cancers. Its expression is induced in response to the tumor suppressor protein p53 and to DNA damage. Ohtsuka et al. have now identified a p53-binding sequence in promoter of the ASC gene.
openaire +1 more source