Results 281 to 290 of about 221,308 (340)

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

Alisertib and Barasertib Induce Cell Cycle Arrest and Mitochondria-Related Cell Death in Multiple Myeloma with Enhanced Efficacy Through Sequential Combination with BH3-Mimetics and Panobinostat. [PDF]

Cancers (Basel)
Benedi A, Beltrán-Visiedo M, Jiménez-Alduán N, Serrano-Del Valle A, Anel A, Naval J, Marzo I.   +6 more
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin-Induced Nephrotoxicity. [PDF]

Basic Clin Pharmacol Toxicol
Demirkapı Atik H, Atik O, Aslan R, Birdane YO, Eryavuz A.   +4 more
europepmc   +1 more source

Cold atmospheric plasma combined with nanoparticles in cancer therapy

Interdisciplinary Medicine, EarlyView.
Cold atmospheric plasma (CAP) generates a range of reactive oxygen and nitrogen species (RONS), including singlet oxygen (1O2), hydrogen peroxide (H2O2), hydroxyl radicals (·OH), nitrate (NO3− ${{\text{NO}}_{3}}^{-}$), and nitrite (NO2− ${{\text{NO}}_{2}}^{-}$), which induce oxidative stress and apoptosis in cancer cells.
Yunhao Wang, Fei Cao, Gbenga A. Martins, Qiujie Fang, Yifan Lin, Zhaowei Chen, Guojun Chen, Zhitong Chen   +7 more
wiley   +1 more source

Galbanic acid alleviates lead acetate-induced reproductive toxicity in prepubertal male wistar rats. [PDF]

Sci Rep
Gharibshahi N, Gazwi HSS, Khosravi M, Khosravi-Farsani S, Khadivi F, Zarei MH.   +5 more
europepmc   +1 more source

Toxicological Response of the BEAS‐2B Cell After Acute Exposure at the Air–Liquid Interface to Ethylbenzene and m‐Xylene Alone and in Binary Mixtures

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzene, toluene, ethylbenzene, and xylenes (o‐, m‐, and p‐xylenes) constitute a family, named BTEX, of volatile organic compounds (VOCs) known for its toxicity. This study aimed to study the acute in vitro toxicity of ethylbenzene and m‐xylene on human bronchial epithelial cells exposed at the air–liquid interface (ALI).
Nour Jaber, Claude Emond, Fabrice Cazier, Sylvain Billet   +3 more
wiley   +1 more source

Short-term stress preconditioning activates sympathetic innervation in the testes to mitigate testicular ischemia-reperfusion injury. [PDF]

J Neuroinflammation
Liu L, Xu R, Li H, Ma Y, Shu Y, Liang H, Wang T, Hao J, Li W, Xiang AP, Jiang MH, Huang W.   +11 more
europepmc   +1 more source

Do Gadolinium‐Based Contrasts Represent a High Risk for Genotoxicity in Mammalian Cells? A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT The scientific rationale for this review stems from the increasing global use of gadolinium‐based contrast agents in medical imaging and the concerns over the long‐term environmental accumulation of gadolinium waste, which may pose biological risks.
Thiago Guedes Pinto, Rogerio Aparecido Dedivits, Daniel Araki Ribeiro   +2 more
wiley   +1 more source

Involvement of hypoxia-inducible factor1-alpha in the protective effect of rivaroxaban against testicular ischemia-reperfusion in rats. [PDF]

Sci Rep
Baset MA, El Awdan SA, Khattab MS, El-Marasy SA.   +3 more
europepmc   +1 more source