Results 21 to 30 of about 221,308 (340)
The in vitro Effect of Doxorubicine-G2-FA Treatment on Breast Cancer Copyright [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: To achieve delivery of a drug to tumors, folic acid (FA) was used as a targeting ligand to change nanocarriers. Since the folate receptor has more expression in several tumor types such as breast cancer. OBJECTIVES: The present study aimed to
Hamed Mansoor Lakooraj +4 more
doaj +1 more source
CONCURRENT EFFECT OF LINUM USITATISSIMUM AND EMBLICA OFFICINALIS ON LEAD INDUCED OXIDATIVE STRESS AND HISTOMORPHOLOGICAL CHANGES IN UTERUS OF FEMALE WISTAR RATS [PDF]
Exploratory Animal and Medical Research, 2022 Lead (Pb) is one of the oldest environmental contaminants and is well known to cause deleterious systemic effects on man and domestic animals including the reproductive system.
Amitava Paul, Karamala Sujatha
doaj +1 more source
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis
EMBO Journal, 2021 During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 members. Here, we report that tBID can also mediate mitochondrial permeabilization by itself, resulting
Hector Flores-Romero +12 more
semanticscholar +1 more source
Two Targets, One Hit: new Anticancer Therapeutics to Prevent Tumorigenesis Without Cardiotoxicity
Frontiers in Pharmacology, 2021 A serious adverse effect of cancer therapies is cardiovascular toxicity, which significantly limits the widespread use of antineoplastic agents. The promising new field of cardio-oncology offers the identification of potent anti-cancer therapeutics that ...
Zoltán Szabó +4 more
doaj +1 more source
Eltrombopag directly inhibits BAX and prevents cell death
Nature Communications, 2021 The BCL-2 family protein BAX has essential activity in mitochondrial regulation of cell death. While BAX activity ensures tissue homeostasis, when dysregulated it contributes to aberrant cell death in several diseases.
A. Spitz +4 more
semanticscholar +1 more source
Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax
Frontiers in Oncology, 2023 The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that, in cellulo, the substitution of S184 by a non-phosphorylatable residue stimulates both the mitochondrial localization of ...
Lilit Simonyan +10 more
doaj +1 more source
Redox Report, 2021 Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation.
Nabila Jahan +5 more
doaj +1 more source
Cell Death and Disease, 2020 Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization (MOMP), which induces the activation of pro-apoptotic caspase cascade.
Lei Hu +6 more
semanticscholar +1 more source
Nature, 2008 Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.
Jerry E. Chipuk, Douglas R. Green
openaire +2 more sources
Berberine induces apoptosis and arrests the cell cycle in multiple cancer cell lines
Archives of Medical Science, 2021 Introduction To examine the anti-cancer effects of berberine on multiple cancer cell lines, and to clarify the underlying molecular mechanisms. Material and methods The IC 50 values for the action of berberine on Tca8113 (oral squamous cell carcinoma),
Qian Li +3 more
doaj +1 more source