Results 21 to 30 of about 150,507 (294)

Puma strikes Bax [PDF]

Journal of Cell Biology, 2009
The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol.
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Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts

Pharmaceutical Biology, 2017
Context: Clinacanthus nutans Lindau (Acanthaceae) is a medicinal plant that has been reported to have anti-inflammatory, antiviral, antimicrobial and antivenom activities.
Peik Lin Teoh, Angelina Ying Fang Cheng, Monica Liau, Fui Fui Lem, Grace P. Kaling, Fern Nie Chua, Bo Eng Cheong   +6 more
doaj   +1 more source

Assessment of the in Vitro Effects of Folate Core–Shell Conjugated Iron Oxide Nanoparticles as a Potential Agent for Acute Leukemia Treatment

Frontiers in Bioscience-Landmark
Background and Objective: There is a growing need to comprehend the potential outcomes of nanoparticles (NPs) on human well-being, including their potential for detecting and treating leukemia.
Ghada M. Nasr, Osama M. Thawabieh, Randa M. Talaat, Mahmoud Moawad, Manal O. El Hamshary   +4 more
doaj   +1 more source

The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

Molecules, 2007
The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in
Xiang-bin Hu, Qing Chang, Xiao-wan Zhu, Bao-ping Han, Yan-qiu Zhang, Yuan-lin Zheng, Zhen Mao   +6 more
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Interaction between Bax and Bcl-XL proteins confirmed by partial acceptor photobleaching-based FRET imaging [PDF]

Journal of Innovative Optical Health Sciences, 2020
Exact interaction mechanism between Bax and Bcl-XL, two key Bcl-2 family proteins, is an interesting and controversial issue. Partial acceptor photobleaching-based quantitative fluorescence resonance energy transfer (FRET) measurement, PbFRET, is a ...
Fangfang Yang, Mengyan Du, Xiaoping Wang, Tongsheng Chen   +3 more
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Cell death: Shadow Baxing [PDF]

Current Biology, 1998
Bcl-2, one of a family of key regulators of apoptosis, was the first cell-death machinery component to be identified, but how the family functions is still not clear. Mammalian Bax, a pro-apoptotic family member, can cause yeast cells to die, and two recent yeast genetic screens shed light on how Bax might function.
Silke, John, Vaux, David L.
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis

Nature Communications, 2023
AbstractThe BCL-2 family protein BAX is a major regulator of physiological and pathological cell death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it undergoes conformational activation and mitochondrial translocation leading to mitochondrial outer membrane permeabilization, a critical event in apoptosis execution ...
Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar MV, Emily H. Cheng, Evripidis Gavathiotis   +5 more
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway [PDF]

Molecular Cell, 2016
Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis and pathological cell death. BAX is predominantly localized in the cytosol, where it has a quiescent monomer conformation. Following a pro-apoptotic trigger, cytosolic BAX is activated and translocates to the mitochondria to initiate mitochondrial dysfunction ...
Thomas P, Garner, Denis E, Reyna, Amit, Priyadarshi, Hui-Chen, Chen, Sheng, Li, Yang, Wu, Yogesh Tengarai, Ganesan, Vladimir N, Malashkevich, Emily H, Cheng, Evripidis, Gavathiotis   +9 more
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Role of microRNA-124-3p/Bax axis in neonatal hypoxic-ischaemic encephalopathy

Biotechnology & Biotechnological Equipment, 2020
Neonatal hypoxic-ischaemic encephalopathy (HIE) is a neurological disease that can cause neonatal death. MicroRNA-124-3p (miR-124-3p) plays an important role in the development of various diseases.
Aiju Chen, Jimei Wang, Fei Luo, Yafang He   +3 more
doaj   +1 more source

Eriodictyol corrects functional recovery and myelin loss in SCI rats

Translational Neuroscience, 2020
This study investigated the therapeutic potential of eriodictyol (EDC) in spinal cord injury (SCI) rats and also the mechanism involved.
Li Chenggang, Wang Chunfang
doaj   +1 more source