Results 21 to 30 of about 317,110 (186)

The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients

Radiology and Oncology, 2023
Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment.
Pravdic Zlatko, Vukovic Nada Suvajdzic, Gasic Vladimir, Marjanovic Irena, Karan-Djurasevic Teodora, Pavlovic Sonja, Tosic Natasa   +6 more
doaj   +1 more source

Armeniacae Semen Regulates Apoptosis and Cell Cycle Progression in MCF-7, MDA-MB-231, and T47D Breast Cancer Cell Lines [PDF]

Middle East Journal of Cancer, 2021
Background: Amygdalin is a glycoside ingredient of rosacea plants that exerts an antitumor effect by blocking the growth of the tumor cells. Therefore, we aimed to use the Armeniacae semen, a member of the Rosacea family, which contains a large amount of
Shiva Mosadegh Manshadi, Fatemeh Nadali, Mohammad Reza Shams Ardekani   +2 more
doaj   +1 more source

Puma strikes Bax [PDF]

Journal of Cell Biology, 2009
The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol.
openaire   +2 more sources

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +5 more sources

Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.

Redox Report, 2021
Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation.
Nabila Jahan, Apu Chowdhury, Ting Li, Ke Xu, Fen Wei, Sicen Wang   +5 more
doaj   +1 more source

Bad expression influences time to androgen escape in prostate cancer [PDF]

, 2007
<b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Bracarda S, Chi KN, Edwards J, Eisenmann KM, Gleave M, Huggins C, Ichinose M, Kelekar A, Lebedeva I, McDonnell TJ   +9 more
core   +1 more source

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis [PDF]

, 2004
A dynamic balance of organelle fusion and fission regulates mitochondrial morphology. During apoptosis this balance is altered, leading to an extensive fragmentation of the mitochondria.
Arnoult, Damien, Chan, David C., Chen, Hsuichen, Karbowski, Mariusz, Smith, Carolyn L., Youle, Richard J.   +5 more
core   +2 more sources

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

Assessment of the in Vitro Effects of Folate Core–Shell Conjugated Iron Oxide Nanoparticles as a Potential Agent for Acute Leukemia Treatment

Frontiers in Bioscience-Landmark
Background and Objective: There is a growing need to comprehend the potential outcomes of nanoparticles (NPs) on human well-being, including their potential for detecting and treating leukemia.
Ghada M. Nasr, Osama M. Thawabieh, Randa M. Talaat, Mahmoud Moawad, Manal O. El Hamshary   +4 more
doaj   +1 more source

Curcumin as an anti-proliferative agent in breast cancer through RASSF1A, Bax, and caspase-3 protein

Сибирский онкологический журнал, 2023
Background. Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specifc mechanism of curcumin cytotoxicity remains controversial because of many anti-
N. A. Rahmah, H. Harliansyah, F. D. Suyatna, M. Kanoko, P. Rustamadji, J. Prihartono, A. Bustami, S. J. Haryono, B. S. Hernowo   +8 more
doaj   +1 more source