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Allostery in BAX protein activation
Journal of Biomolecular Structure and Dynamics, 2016BAX is a member of the proapoptotic BCL-2 family of proteins, which is involved in the regulation of the intrinsic pathway of apoptosis. In the process of apoptosis, BH3-only molecules activate cytosolic BAX. Activated BAX molecules insert into the mitochondrial outer membrane with their [Formula: see text]-helix and form oligomers that lead to ...
Hansi Zhang+2 more
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HSP60, Bax, and Cardiac Apoptosis
Cardiovascular Toxicology, 2003HSP60 has long been known as an important chaperonin and as having key folding functions within the mitochondria. However, it has now become evident that significant amounts of HSP60 are found in extra-mitochondrial locations. This extra-mitochondrial HSP60 in the heart has key anti-apoptotic functions. Extra-mitochondrial HSP60 complexes with both bax
Anne A Knowlton, Sanjiv Gupta
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Science's STKE, 2007
At about age 50, depletion of ovarian follicles through apoptosis leads to the loss of cyclic ovarian function in women. Menopause, in turn, is believed to set the stage for various health problems. Although aging female mice do not undergo menopause, they experience depletion of ovarian follicles and health complications similar to those ...
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At about age 50, depletion of ovarian follicles through apoptosis leads to the loss of cyclic ovarian function in women. Menopause, in turn, is believed to set the stage for various health problems. Although aging female mice do not undergo menopause, they experience depletion of ovarian follicles and health complications similar to those ...
openaire +2 more sources