Results 41 to 50 of about 221,308 (340)
Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis
Nature Communications, 2023 AbstractThe BCL-2 family protein BAX is a major regulator of physiological and pathological cell death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it undergoes conformational activation and mitochondrial translocation leading to mitochondrial outer membrane permeabilization, a critical event in apoptosis execution ...
Nadege Gitego +5 more
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MCL-1 Inhibits BAX in the Absence of MCL-1/BAX Interaction [PDF]
Journal of Biological Chemistry, 2008 The BCL-2 family of proteins plays a major role in the control of apoptosis as the primary regulator of mitochondrial permeability. The pro-apoptotic BCL-2 homologues BAX and BAK are activated following the induction of apoptosis and induce cytochrome c release from mitochondria.
Marc Germain +2 more
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4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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Interaction between Bax and Bcl-XL proteins confirmed by partial acceptor photobleaching-based FRET imaging [PDF]
Journal of Innovative Optical Health Sciences, 2020 Exact interaction mechanism between Bax and Bcl-XL, two key Bcl-2 family proteins, is an interesting and controversial issue. Partial acceptor photobleaching-based quantitative fluorescence resonance energy transfer (FRET) measurement, PbFRET, is a ...
Fangfang Yang +3 more
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Eriodictyol corrects functional recovery and myelin loss in SCI rats
Translational Neuroscience, 2020 This study investigated the therapeutic potential of eriodictyol (EDC) in spinal cord injury (SCI) rats and also the mechanism involved.
Li Chenggang, Wang Chunfang
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Effect of high-intensity interval training on expression of pro and anti-apoptotic genes in myocard tissue of aged male C57BL/6 mice [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2019 Purpose: Bax and BCL-2 genes are important genes that involve in the intrinsic pathway of apoptosis. Although the effects of interval and intensive exercises on the mechanisms involved in the gaining processes are less considered.
Rahman Soori +3 more
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Armeniacae Semen Regulates Apoptosis and Cell Cycle Progression in MCF-7, MDA-MB-231, and T47D Breast Cancer Cell Lines [PDF]
Middle East Journal of Cancer, 2021 Background: Amygdalin is a glycoside ingredient of rosacea plants that exerts an antitumor effect by blocking the growth of the tumor cells. Therefore, we aimed to use the Armeniacae semen, a member of the Rosacea family, which contains a large amount of
Shiva Mosadegh Manshadi +2 more
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Mitochondrial Fusion: Bax to the Fussure [PDF]
Developmental Cell, 2011 Mitochondria can be organized into highly interconnected networks through continuous cycles of fission and fusion. A recent study by Hoppins et al. (2011) published in Molecular Cell now suggests that Bax, more commonly known for its role in apoptosis, can promote mitochondrial fusion in a Mitofusin 2-dependent manner.
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BAX and BAK Caught in the Act [PDF]
Molecular Cell, 2009 In this issue of Molecular Cell, Kim et al. (2009) describe the steps involved in the direct activation of the proapoptotic proteins BAX and BAK by their BH3-only partners, resolving the controversy regarding direct versus indirect activation of these proteins.
Yong Yao, Francesca M. Marassi
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Multistep and multitask Bax activation [PDF]
Mitochondrion, 2010 Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pathway, and amplifying that one occurring via the extrinsic, receptor mediated pathway. Bax is present in viable cells and activated by pro-apoptotic stimuli.
GHIBELLI, LINA, Diederich, M.
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