Multistep and multitask Bax activation [PDF]
Mitochondrion, 2010 Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pathway, and amplifying that one occurring via the extrinsic, receptor mediated pathway. Bax is present in viable cells and activated by pro-apoptotic stimuli.
GHIBELLI, LINA, Diederich, M.
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Frontiers in Pharmacology, 2023 Background: Herbs originating from the Aconitum L. (Ranunculaceae), such as Aconitum carmichaelii Debeaux. (Wutou), Aconitum pendulum Busch. (Tiebangchui), and Aconitum kusnezoffii Reichb. (Caowu), etc.
Gelin Xiang +7 more
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BAX and BAK Caught in the Act [PDF]
Molecular Cell, 2009 In this issue of Molecular Cell, Kim et al. (2009) describe the steps involved in the direct activation of the proapoptotic proteins BAX and BAK by their BH3-only partners, resolving the controversy regarding direct versus indirect activation of these proteins.
Yong Yao, Francesca M. Marassi
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Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts
Pharmaceutical Biology, 2017 Context: Clinacanthus nutans Lindau (Acanthaceae) is a medicinal plant that has been reported to have anti-inflammatory, antiviral, antimicrobial and antivenom activities.
Peik Lin Teoh +6 more
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Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
Czech Journal of Animal Science, 2013 Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture.
M. Sedmíková +7 more
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Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid: BAX/BCL-2 and Tyr genes expression and evaluation of nanomechanical properties in A375 human melanoma cell line [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Humic acid (HA) and Fulvic acid (FA) are major members of humic substances, which are extracted from organic sources including soil and peat.
Mitra Salehi +4 more
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Biphasic translocation of Bax to mitochondria [PDF]
Biochemical Journal, 2002 Using green fluorescent protein-tagged Bax, we demonstrate that Bax is sequestered from the cytosol of cardiomyocytes in two distinct phases following the induction of apoptosis with staurosporine. In the first phase, lasting several hours, Bax removal from the cytosol was relatively small.
Michela Capano, Martin Crompton
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Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis [PDF]
, 2004 A dynamic balance of organelle fusion and fission regulates mitochondrial morphology. During apoptosis this balance is altered, leading to an extensive fragmentation of the mitochondria.
Arnoult, Damien +5 more
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Allosteric sensitization of proapoptotic BAX [PDF]
Nature Chemical Biology, 2017 BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein.
Pritz, Jonathan R. +10 more
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BAX: A dedicated X-Rays galaxy clusters Database [PDF]
, 2003 We present BAX, Base de Donn\'ees amas de galaxies X (http://webast.ast.obs-mip.fr/bax), a project aiming at building a comprehensive database dedicated to X-rays clusters of galaxies allowing detailed information retrieval. BAX provides the user with {\it basic data} published in the literature on X-rays clusters of galaxies as well as with ...
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