Results 51 to 60 of about 235,115 (280)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Incident Cause Pattern Analysis at Bayer

Chemical Engineering Transactions, 2016
A detailed investigation of each occurred LoPC incident is essential for Bayer to improve safety, avoid future incidents and to strengthen safety awareness.
Jan Weppelmann
doaj   +1 more source

Liquid chromatographic analysis of geological organic substances of industrial importance [PDF]

, 2005
University of Technology, Sydney. Faculty of Science.Soluble organic species called humic substances are important in the Bayer process due to their adverse effect on the industrial scale production of alumina from bauxite.
Whelan, T
core  

Regression Based Expected Shortfall Backtesting

, 2019
This paper introduces novel backtests for the risk measure Expected Shortfall (ES) following the testing idea of Mincer and Zarnowitz (1969). Estimating a regression framework for the ES stand-alone is infeasible, and thus, our tests are based on a joint
Bayer, Sebastian, Dimitriadis, Timo
core   +1 more source

Dynamic programming for optimal stopping via pseudo-regression [PDF]

, 2018
We introduce new variants of classical regression-based algorithms for optimal stopping problems based on computation of regression coefficients by Monte Carlo approximation of the corresponding $L^2$ inner products instead of the least-squares error ...
Bayer, Christian, Redmann, Martin, Schoenmakers, John   +2 more
core   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A Self-Consistent, High-Fidelity Adsorption Model for Chromatographic Process Predictions: Low-to-High Load Density and Charge Variants in a Preparative Cation Exchanger

Separations
The development of ion exchange chromatography to polish biopharmaceuticals requires extensive experimental benchmarking. As part of the Design of Experiments (DoE), statistical models increased efficiency somewhat and are still state of the art; however,
Gregor M. Essert, Marko Tesanovic, Sonja Berensmeier, Isabell Hagemann, Peter Schwan   +4 more
doaj   +1 more source

Enhanced Precipitation of Gibbsite from Sodium Aluminate Solution by Adding Agglomerated Active Al(OH)₃ Seed

Metals, 2023
The addition of active seed for increasing the precipitation rate leads to the formation of fine Al(OH)3 particles that complicates separation of solid from the mother liquor.
Andrei Shoppert, Dmitry Valeev, Konstantin Alekseev, Irina Loginova   +3 more
doaj   +1 more source

Seeds of Change: Impact of Interventions by Bayer and Monsanto on the Elimination of Child Labour on Farms Producing Hybrid Cottonseed in India [PDF]

, 2007
seeds_of_change_final.pdf: 700 downloads, before Oct.
Venkateswarlu, Davuluri
core   +1 more source

Moduli spaces of sheaves on K3 surfaces [PDF]

, 2016
In this survey article we describe moduli spaces of simple, stable, and semistable sheaves on K3 surfaces, following the work of Mukai, O'Grady, Huybrechts, Yoshioka, and others.
Sawon, Justin
core   +3 more sources